HKI5MAG-99K

MILLIPLEX^® Human Kidney Injury Magnetic Bead Panel 5 - Toxicity Multiplex Assay

The analytes available for this multiplex kit are: α-1-Microglobulin, Collagen IV, Lipocalin-2/NGAL, Osteoactivin, TIMP-1, Uromodulin.

• Código UNSPSC: 12161503
• eCl@ss: 32161000
• NACRES: NA.84

Propiedades

• Nivel de calidad: 200
• reactividad de especies: human
• fabricante / nombre comercial: Milliplex^®
• assay range: accuracy: 62-90%; intra-assay cv: <10; sensitivity: 0.05-0.56 ng/mL; (MinDC+2SD); standard curve range: 0.05-50 ng/mL; (Lipocalin-2/NGAL); standard curve range: 0.05-50 ng/mL; (Uromodulin); standard curve range: 0.10-100 ng/mL; (TIMP-1); standard curve range: 0.20-200 ng/mL; (Osteoactivin); standard curve range: 0.24-250 ng/mL; (α-1-Microglobulin); standard curve range: 0.49-500 ng/mL; (Collagen IV)
• técnicas: multiplexing: suitable
• método de detección: fluorometric (Luminex xMAP)
• Condiciones de envío: wet ice

Descripción

Descripción general

Maintenance of physiological balance in the body is attributed in part to normal kidney function. Altered kidney function due to injury, drug toxicity or kidney failure may be life threatening. Toxicity is the leading cause of drug failure, so research is expanding in search of more sensitive, rapid methods to determine organ-specific damage as quickly as possible. Traditionally, blood urea nitrogen (BUN) and serum creatinine tests have been used to determine drug-induced damage to the kidney. These tests only detect kidney damage after it begins and do not allow for the elucidation of where in the kidney the damage has occurred. Specificity and earlier detection of kidney injury is vital, and this area of research is expanding in search of more sensitive, rapid methods for determining the specific area of damage in kidney.

The MILLIPLEX^® portfolio provides valuable research assays to investigate multiple biomarkers of kidney injury in human serum and plasma samples using the Luminex^® xMAP^® instrument platform.

The MILLIPLEX^® Human Kidney Injury Bead Panel 5 contains all the components necessary to measure the following six biomarkers in any combination using Luminex^® xMAP^® technology: α-1-Microglobulin, Collagen IV, Lipocalin-2/NGAL, Osteoactivin, TIMP-1, Uromodulin. The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.

Panel Type: Toxicity

Especificidad

There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.

Aplicación

• Analytes: α-1-Microglobulin, Collagen IV, Lipocalin-2/NGAL, Osteoactivin, TIMP-1, Uromodulin
• Recommended Sample type: serum and plasma
• Recommended Sample dilution: 1:75 in kit Assay Buffer. Customers should determine the optimal dilution factor for their samples. Our recommendations are based on serum and plasma samples from normal subjects
• Assay Run Time: Overnight
• Research Category: Inflammation & Immunology

Características y beneficios

Design your multiplex kit by choosing available analytes within this panel.

Envase

Everything you need in a single kit.

Almacenamiento y estabilidad

Recommended storage for kit components is 2 - 8°C.

Otras notas

Please contact Technical Service for linearity of dilution.

Sensitivity: Please see kit protocol for individual assay sensitivities.

Información legal

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS05,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H302 + H332,H311,H317,H318,H373,H411
• Consejos de prudencia: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
• Órganos de actuación: Respiratory Tract
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects