444278-M

MMP-9 Inhibitor I

≥93% (HPLC), solid, MMP-9 inhibitor, Calbiochem^®

• Sinónimos: MMP-9 Inhibitor I
• Fórmula empírica (notación de Hill): C₂₇H₃₃N₃O₅S
• Número de CAS: 1177749-58-4
• Peso molecular: 511.63
• Número MDL: MFCD22581508
• Código UNSPSC: 12352200

Propiedades

• Nombre del producto: MMP-9 Inhibitor I, MMP-9 Inhibitor I, CAS 1177749-58-4, is a cell-permeable, potent, and reversible MMP-9 Inhibitor (IC₅₀ = 5 nM). At high concentration inhibits MMP-1 (IC₅₀ = 1.05 µM) & MMP-13 (IC₅₀ = 113 nM).
• Nivel de calidad: 100
• Ensayo: ≥93% (HPLC)
• Formulario: solid
• potencia: 5 nM IC₅₀
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: off-white
• solubilidad: DMSO: 10 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: [S](=O)(N(Cc3ccccc3)c2c(cc(cc2C(=O)NO)CN(CC)CC)C)Oc1ccc(cc1)OC
• InChI: 1S/C27H33N3O5S/c1-5-29(6-2)18-22-16-20(3)26(25(17-22)27(31)28-32)30(19-21-10-8-7-9-11-21)36(33)35-24-14-12-23(34-4)13-15-24/h7-17,32H,5-6,18-19H2,1-4H3,(H,28,31)
• Clave InChI: OIYCVCCJVZCTIX-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable, potent, selective, and reversible MMP-9 Inhibitor (IC₅₀ = 5 nM). Inhibits MMP-1 (IC₅₀ = 1.05 µM) and MMP-13 (IC₅₀ = 113 nM) only at much higher concentrations.

A cell-permeable, potent, selective, and reversible inhibitor of MMP-9 (IC₅₀ = 5 nM). Also inhibits MMP-1 (IC₅₀ = 1.05 µM) and MMP-13 IC₅₀ = 113 nM) at higher concentrations.

Acciones bioquímicas o fisiológicas

Primary Target
MMP-9

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Levin, J.I., et al. 2001. Bioorg. Med. Chem. Lett.11, 2189.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable