344282

Forskolin

from Coleus forskohlii, ≥97% (HPLC), liquid, positive inotropic agent, Calbiochem

• Sinónimos: Forskolin, Coleus forskohlii in DMSO
• Fórmula empírica (notación de Hill): C₂₂H₃₄O₇
• Peso molecular: 410.50
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: Forskolin, Coleus forskohlii in DMSO, The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii.
• Nivel de calidad: 100
• Ensayo: ≥97% (HPLC)
• Formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C

Descripción

Descripción general

The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii.

The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC₅₀ = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na⁺ permeability that results in indirect augmentation of Ca²⁺ release. Inhibits MAP kinase in rat renal mesangial cells (IC₅₀ = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.

The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC₅₀ = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na⁺ permeability that results in indirect augmentation of Ca²⁺ release. Inhibits MAP kinase in rat renal mesangial cells (IC₅₀ = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. The solid form of this compound (Cat. No. 344270) is also available.

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Forma física

A 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.

Reconstitución

Following initial thaw, aliquot and freeze (-20°C).

Otras notas

D′Orazio, J.A., et al. 2006. Nature443, 340.
Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun.219, 180.
Galli, C., et al. 1995. J. Neurosci.15, 1172.
Li, X., et al. 1995. Am. J. Physiol.269, C986.
Lomo, J., et al. 1995. J. Immunol.154, 1634.
Uneyama, H., et al. 1993. J. Biol. Chem.268, 168.
Laurenza, A., et al. 1989. Trends Pharmacol. Sci.10, 442.
Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem.31, 217.
Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res.20, 1.
Huang, R., et al. 1982. Cyclic Nucleotide Res.8, 385.
Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol.9, 99.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 188.6 °F - (refers to pure substance)
• Punto de inflamabilidad (°C): 87 °C - (refers to pure substance)