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Documentos clave

189725

Sigma-Aldrich

Avidin, Egg White

Sinónimos:

Avidin, Egg White

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About This Item

Número de CAS:
Número MDL:
Código UNSPSC:
41116133
NACRES:
NA.41

descripción

Merck USA index - 14, 886

Nivel de calidad

Formulario

lyophilized solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze

color

white

solubilidad

dilute buffer: 5 mg/mL
distilled water: 5 mg/mL

Condiciones de envío

ambient

temp. de almacenamiento

−20°C

Descripción general

Avidin is a tetrameric glycoprotein and an anti-nutrient found in the eggs of all oviparous vertebrates. It constitutes 0.05–0.5% of the total protein in hen eggs. Avidin structure contains eight orthogonal antiparallel β-strands, a single disulfide bond, and a carbohydrate side chain.

Aplicación

Avidin, Egg White has been used as a blocking agent in protein-binding assays. It has also been used to form avidin-biotin linkage to conjugate gemcitabine onto microbubbles for drug delivery to in vivo model.

Acciones bioquímicas o fisiológicas

Avidin can be used as a label for antibodies, fluorescent dyes, proteins,, and other molecules of interest to biochemists. The high binding affinity of avidin to biotin (vitamin H) causes the unavailability of biotin to microorganisms, which leads to the inhibition of their proliferation. This feature of avidin contributes to its antimicrobial property and affects biotin absorption in the body, resulting in vitamin B7 deficiency.

Advertencia

Toxicity: Standard Handling (A)

Definición de unidad

One unit is defined as the amount of avidin that will bind 1 µg D-biotin at pH 8.9.

Reconstitución

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Avoid freeze/thaw cycles.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Eric A Berg et al.
Cold Spring Harbor protocols, 2020(7), 099242-099242 (2020-07-03)
This introduction outlines general strategies for labeling proteins, with an emphasis on methods that are used primarily for labeling antibodies. It covers the specific site of modification, cross-linker options, types of labels, and postlabeling cleanup methodology, along with the advantages
Visualizing structural changes of egg avidin to thermal and electric field stresses by molecular dynamics simulation
Zhu Y, et al.
LWT--Food Science and Technology, 151, 112139-112139 (2021)
Jia-Ling Ruan et al.
International journal of radiation oncology, biology, physics, 109(5), 1472-1482 (2021-03-15)
Chemoradiation therapy is the standard of care in muscle-invasive bladder cancer (MIBC). Although agents such as gemcitabine can enhance tumor radiosensitivity, their side effects can limit patient eligibility and treatment efficacy. This study investigates ultrasound and microbubbles for targeting gemcitabine
Eva Krkavcová et al.
Biology open, 7(4) (2018-03-16)
Avidin is a key egg white antimicrobial protein with strong binding capacity for biotin, an essential growth and immune cell precursor. As such, it is assumed to have a pronounced, though still poorly explored, effect on hatchling phenotype. We tested
Mu A et al.
Nature cell biology, 21(5), 592-602 (2019-04-10)
Inverted formin 2 (INF2) is a member of the formin family of actin assembly factors. Dominant missense mutations in INF2 are linked to two diseases: focal segmental glomerulosclerosis, a kidney disease, and Charcot-Marie-Tooth disease, a neuropathy. All of the disease

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