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1.16881

Millipore

Fractogel® EMD TMAE (M)

Sinónimos:

Biochromatography, Fractogel® Ion exchangers, Ion exchanger for LC (Fractogel® TSK/EMD), Fractogel® EMD TMAE (M)

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About This Item

UNSPSC Code:
41115711

ligand

(Trimethylammoniumethyl)

Quality Level

400

description

strong anion exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)

sterility

sterile (Caustic Stable)

product line

Fractogel®

form

resin

parameter

240 cm/hr flow rate
8 bar max. pressure

matrix active group

methacrylate

mean particle size

40-90 μm

capacity

100 mg binding capacity (BSA/mg of resin)

transition temp

flash point 35 °C (calculated)

density

1.430 g/cm3 at 20 °C

bulk density

1000 kg/m3

application(s)

gene therapy
mAb
recombinant protein

separation technique

anion exchange
strong anion exchange

storage temp.

no temp limit

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General description

Strong anion exchange Fractogel® resin featuring the tentacle technology with a trimethylammoniumethyl functional group, for purification of acidic and neutral proteins and peptides from multiple sources, DNA and virus removal, plasmid isolation, vaccine purification, and more

Features and Benefits

Fractogel® EMD TMAE (M) enables:

  • High protein loading conditions resulting in good selectivity and resolution with the tentacle technology
  • Excellent binding to large viruses at increased loading
  • Homogenous binding with high selectivity and purity
  • Reduce operating costs and resin replacement with enduring durability - allowing for multiple cycles of column regeneration and sanitization
  • Compatibility with 2.5 % (v/v) aqueous benzyl alcohol containing 150 mM NaCl storage solution

Packaging

  • 1.16881.0100: Fractogel® EMD TMAE (M) Resin 100ml
  • 1.16881.0010: Fractogel® EMD TMAE (M) Resin 10ml
  • 1.16881.0500: Fractogel® EMD TMAE (M) Resin 500ml
  • 1.16881.0050: Fractogel® EMD TMAE (M) Resin 50ml
Plastic bottle

Analysis Note

Appearance: Milky turbid suspension, free from impurities (foreign particles)
Microscopic evaluation: Uniform spherical particles,no agglomerates,no fines
Extractable matter (water): ≤ 0.03 %
Cerium: ≤ 1 µg/g
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 1.0 bar
Particle size (d10): 37 - 45 µm
Particle size (d50): 48 - 60 µm
Particle size (d90): 63 - 77 µm
Colony forming units (TAMC + TYMC): ≤ 100 CFU/ml
Endotoxins: ≤ 1.00 EU/ml
Protein binding capacity (bovine serum albumin): 80 - 120 mg/ml
Functional test (b:a): ≤ 0.25
Functional test: Separation of conalbumin and human serum albumin

Legal Information

FRACTOGEL is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Flame
GHS02

signalword

Warning

hcodes

H226

Hazard Classifications

Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

95.0 °F

flash_point_c

35 °C

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Artículos

Egg-based and Cell-based Influenza Vaccine Manufacturing Methods

Influenza vaccines are commonly made using egg-based and cell-based manufacturing strategies. Find step-by-step information on the manufacturing process for each method.

Cost Modeling Vaccine Manufacturing: Estimate Production Costs for mRNA and other Vaccine Modalities

A custom-designed cost model is used to explore the economics of vaccine manufacturing across several different modalities including mRNA. The model enables greater process understanding, simulates bottlenecks, and helps to optimize production efficiency.

Cost Modeling Vaccine Manufacturing: Estimate Production Costs for mRNA and other Vaccine Modalities

A custom-designed cost model is used to explore the economics of vaccine manufacturing across several different modalities including mRNA. The model enables greater process understanding, simulates bottlenecks, and helps to optimize production efficiency.

Cost Modeling Vaccine Manufacturing: Estimate Production Costs for mRNA and other Vaccine Modalities

A custom-designed cost model is used to explore the economics of vaccine manufacturing across several different modalities including mRNA. The model enables greater process understanding, simulates bottlenecks, and helps to optimize production efficiency.

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