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P-078

Supelco

R-(-)-Phenylephrine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C9H14ClNO2
Número de CAS:
61-76-7
Peso molecular:
203.67
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

Cl.CNC[C@H](O)c1cccc(O)c1

InChI

1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

InChI key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

General description

Phenylephrine, marketed as Neo-Synephrine®, is the most common over-the-counter (OTC) decongestant in the US. Over the last few years, it has been marketed as a substitute for pseudoephedrine with tighter US government regulation of pseudoephedrine from the Combat Methamphetamine Epidemic Act of 2005.

Application

  • Stability-Indicating Assay for Ibuprofen and Phenylephrine hydrochloride: A high-performance liquid chromatography (HPLC) method was developed for the eco-friendly and stability-indicating assay of a binary mixture containing phenylephrine hydrochloride, highlighting its role in pharmaceutical quality control and formulation research (Kelani et al., 2023).
  • Visual Attention and Adrenergic Manipulation: The differential effects of dopaminergic and noradrenergic manipulations, including the use of phenylephrine, on attention were studied using the theory of visual attention in rat models, providing insights into the neuropharmacological impacts of adrenergic receptor agonists (Hervig et al., 2023).
  • Chemometric Quality Assessment: Comparative UV-spectrophotometric analysis using predictive models for the quality assessment of phenylephrine HCl and paracetamol, which is crucial for ensuring the chiral purity and efficacy of pharmaceutical formulations (Farid et al., 2022).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Neo-Synephrine is a registered trademark of Bayer Healthcare LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Related product

Referencia del producto
Descripción
Precios

E-011

(1S,2R)-(+)-Ephedrine hydrochloride, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

E-023

(1R,2S)-(−)-Ephedrine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

E-025

(1S,2R)-(+)-Ephedrine-d3 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

E-026

(1S,2R)-(+)-Ephedrine-d3 hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

M-129

(1R,2S)-(-)-N--Methylephedrine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-043

(±)-Norephedrine-d3 hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

N-046

(+)-Norpseudoephedrine hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

P-035

(S,S)-(+)-Pseudoephedrine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-036

(R,R)-(-)-Pseudoephedrine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-038

(±)-Phenylpropanolamine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

P-056

(1S,2S)-(+)-Pseudoephedrine-d3 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

P-079

(±)-Phenylephrine-d3 hydrochloride solution, 100 μg/mL in methanol with 5% 1 M HCl (as free base), ampule of 1 mL, certified reference material, Cerilliant®

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

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Abiodun Adefurin et al.
Hypertension (Dallas, Tex. : 1979), 61(4), 915-920 (2013-02-13)
Blacks have increased hemodynamic responses to both physiological and pharmacological adrenergic stimulation compared with whites, and this may contribute to the greater prevalence of hypertension in this ethnic group. A small study suggested enhanced α1-adrenoreceptor-mediated arterial vasoconstriction in the forearm
J Bautista-Ortega et al.
Poultry science, 92(4), 1062-1072 (2013-03-09)
The effects of supplemental l-arginine (Arg), vitamin E (VE), and vitamin C (VC) on vascular reactivity to phenylephrine (PE) were examined in clinically healthy hypoxemic male broiler chickens. One-day-old chicks were housed in wire cages and randomly allocated to 1
Kyungjin Lee et al.
BMC complementary and alternative medicine, 13, 31-31 (2013-02-16)
Prunus yedoensis Matsum. is used as traditional medicine-'Yaeng-Pi' or 'Hua-Pi'-in Japan and Korea. However, no studies have examined the pharmacological activities of the P. yedoensis bark. Only the antioxidant and antiviral activities of P. yedoensis fruit and the anti-hyperglycaemic effect
Claire W A Pennekamp et al.
Trials, 14, 43-43 (2013-02-16)
Intraoperative arterial hypotension can lead to severe complications in patients undergoing carotid endarterectomy, in particular if cerebral auto-regulation is impaired. Short-acting agents, such as phenylephrine or ephedrine, commonly used to correct intra-operative hypotension, have different hemodynamic effects. Recently, it was
Doreen Schmidl et al.
Investigative ophthalmology & visual science, 54(3), 1964-1970 (2013-02-27)
We determined whether administration of a nitric oxide synthase (NOS) inhibitor alters optic nerve head blood flow (ONHBF) regulation during isometric exercise in healthy subjects. Our study was done in a randomized, placebo-controlled, double-masked, three-way crossover design. A total of
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