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M-007

Supelco

(±)-Methadone solution

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C21H27NO
Número de CAS:
76-99-3
Peso molecular:
309.45
EC Number:
200-659-6
MDL number:
MFCD00056289
UNSPSC Code:
41116107
PubChem Substance ID:
329817685
NACRES:
NA.24

grade

certified reference material

form

liquid

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

CCC(C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)=O

InChI

1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3

InChI key

USSIQXCVUWKGNF-UHFFFAOYSA-N

Gene Information

human ... OPRM1(4988)

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General description

Methadone is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. The drug is sold under several trade names such as Symoron, Dolophine®, Amidone, Methadose®, Physeptone, or Heptadon. This Certified Spiking Solution® is suitable for LC/MS or GC/MS testing methods in pain prescription monitoring, forensic analysis or clinical toxicology.

Application


  • Neurobehavioral and Molecular Changes in a Rodent Model: This study leverages Imipramine hydrochloride in a rodent model to investigate ACTH-induced HPA axis dysfunction, focusing on its effects on neurobehavior and molecular signaling pathways. This research underscores the utility of Imipramine hydrochloride in studying stress-related neuropsychiatric disorders, enhancing understanding of its therapeutic mechanisms in clinical settings (Sallie et al., 2024).

  • Electrochemical DNA Biosensor Development: Imipramine hydrochloride is used in the development of novel electrochemical DNA biosensors, highlighting its role in enhancing the sensitivity and specificity of genetic analysis. This application is pivotal in biotechnological advancements for genomics and personalized medicine (Augustín et al., 2024).

  • Diabetic Peripheral Neuropathy: Prevention and Treatment: Research incorporating Imipramine hydrochloride focuses on its effectiveness in managing symptoms of diabetic peripheral neuropathy, providing insights into its analgesic properties and mechanisms of action in nerve pain management, which is crucial for developing better therapeutic strategies (Bragg et al., 2024).

  • Microvesicle Particles in Burn Injury: Utilizes Imipramine hydrochloride in a study investigating the role of microvesicle particles in mediating damage in burn injury cases, offering a new perspective on the systemic impacts of burn injuries and the potential interventions to mitigate these effects (Lohade et al., 2024).

  • Sustainable Biosensor for Tricyclic Antidepressants: Highlights the use of Imipramine hydrochloride in the development of sustainable beeswax modified cellulose paper for the detection of tricyclic antidepressants in biofluids. This innovative approach represents a significant step forward in environmental sustainability and drug monitoring technologies (González-Bermúdez et al., 2024).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Dolophine is a registered trademark of Roxane Laboratories, Inc.
Methadose is a registered trademark of Mallinckrodt Inc.

related product

Referencia del producto
Descripción
Precios

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

O-020

Opiate Multi-component Mixture-5 solution, 250 μg/mL each component in methanol, ampule of 1.0 mL, certified reference material, Cerilliant®

E-006

EDDP perchlorate, ampule of 10 mg, certified reference material, Cerilliant®

E-021

EDDP-D3 perchlorate solution, 100 μg/mL in methanol (as pyrrolinium), ampule of 1 mL, certified reference material, Cerilliant®

E-022

EDDP perchlorate solution, 1.0 mg/mL in methanol (as pyrolinium), ampule of 1 mL, certified reference material, Cerilliant®

E-057

EMDP hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

E-062

EDDP-D3 perchlorate solution, 1.0 mg/mL in methanol (as pyrrolinium), ampule of 1 mL, certified reference material, Cerilliant®

M-008

(±)-Methadone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-019

(±)-Methadone solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-021

(±)-Methadone-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-088

(±)-Methadone-D9 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-089

(±)-Methadone-D9 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Maintenance medication for opiate addiction: the foundation of recovery.
Bart G.
Journal of Addictive Diseases, 31(3), 207-225 (2012)
David Kao et al.
Annals of internal medicine, 158(10), 735-740 (2013-05-22)
Long-acting opioids are a leading cause of accidental death in the United States, and methadone is associated with greater mortality rates. Whether this increase is related to the proarrhythmic properties of methadone is unclear. To describe methadone-associated arrhythmia events reported
Advice on methadone and oral health: dental public health in action.
C M Jones et al.
Community dental health, 30(2), 68-70 (2013-07-31)
Philippa Hawley et al.
Pain research & management, 18(2), 83-86 (2013-05-11)
Methadone is one of the most important medications used for the treatment of refractory pain in the palliative care setting, and is usually initially prescribed by one of a limited number of physicians who have acquired authorization for its use.
The lethal burden of drug overdose.
Lancet (London, England), 382(9895), 833-833 (2013-09-10)
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