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Documentos

A0424

Sigma-Aldrich

Alverine citrate salt

Sinónimos:

N-Ethyl-3,3′-diphenyldipropylamine, NSC 35459

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About This Item

Fórmula empírica (notación de Hill):
C20H27N · C6H8O7
Número de CAS:
5560-59-8
Peso molecular:
473.56
EC Number:
226-929-3
MDL number:
MFCD00035086
UNSPSC Code:
12352100
PubChem Substance ID:
57653816
NACRES:
NA.22

form

powder

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CCCc1ccccc1)CCCc2ccccc2

InChI

1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

RYHCACJBKCOBTJ-UHFFFAOYSA-N

Gene Information

human ... HNF4A(3172) , HTR1A(3350)

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Application

Used for studies of pharmacological activity including:
  • Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
  • Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
  • Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
  • Drug effects viewed from a signal transduction network perspective
  • Enhanced cytotoxic effect of proteasome inhibitor MG132
  • Mechanism of action on phasic smooth muscles

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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M Bouvier et al.
Gastroenterologie clinique et biologique, 16(4), 334-338 (1992-01-01)
To analyse the mechanisms of the antispasmodic action of alverine, the effects of this drug on the spontaneous motility and nervous control of the proximal colon of the rabbit were studied in vivo. The electrical activity of the colonic smooth
A general practice study to compare alverine citrate with mebeverine hydrochloride in the treatment of irritable bowel syndrome.
G J Tudor
The British journal of clinical practice, 40(7), 276-278 (1986-07-01)
A Abysique et al.
Alimentary pharmacology & therapeutics, 13(4), 561-566 (1999-04-24)
Alverine citrate is commonly used in the treatment of painful affections of the colon. To determine whether alverine citrate acts on the vagal sensory endings. Unitary recordings were performed at the level of the vagal fibres in the nodose ganglion
A M Coelho et al.
The Journal of pharmacy and pharmacology, 53(10), 1419-1426 (2001-11-08)
Serotonin (5-HT) is considered as a major mediator causing hyperalgesia and is involved in inflammatory reactions and irritable bowel syndrome. Alverine citrate may possess visceral antinociceptive properties in a rat model of rectal distension-induced abdominal contractions. This study was designed
Mehmet Arhan et al.
World journal of gastroenterology, 10(15), 2303-2304 (2004-07-20)
Alverine citrate is a commonly used smooth muscle relaxant agent. A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent. A 34-year-old woman was investigated because of the finding of elevated liver function tests
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