931853
SPhos Pd G6 acylation
≥95%
Sinónimos:
(SPhos)Pd(4-CH2CH2CONHSPh)Br
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About This Item
Fórmula empírica (notación de Hill):
C39H47BrNO6PPd
Número de CAS:
Peso molecular:
843.09
UNSPSC Code:
12352100
NACRES:
NA.21
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Quality Level
assay
≥95%
form
powder
reaction suitability
reagent type: catalyst
reaction type: Cross Couplings
Application
SPhos Pd G6 acylation is an oxidative addition complex (OAC) of SPhos for use in bioconjugation. The pendant NHS-functional group allows coupling to protein amines through a selective acylation. The protein-OAC can then be reacted with a second, cysteine-containing protein. This facile approach allows for protein homodimerization as well as the formation of antibody-protein conjugates.
Learn more about G6 Buchwald precatalysts
Learn more about G6 Buchwald precatalysts
related product
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Muhammad Jbara et al.
Angewandte Chemie (International ed. in English), 60(21), 12109-12115 (2021-03-18)
Organometallic reagents enable practical strategies for bioconjugation. Innovations in the design of water-soluble ligands and the enhancement of reaction rates have allowed for chemoselective cross-coupling reactions of peptides and proteins to be carried out in water. There are currently no
Heemal H Dhanjee et al.
Journal of the American Chemical Society, 142(51), 21237-21242 (2020-12-16)
Palladium oxidative addition complexes (OACs) are traditionally accessed by treating an aryl halide-containing substrate with a palladium(0) source. Here, a new strategy to selectively prepare stable OACs from amino groups on native proteins is presented. The approach relies on an
Ryan P King et al.
Organic letters, 23(20), 7927-7932 (2021-10-07)
The utilization of isolated Palladium Oxidative Addition Complexes (OACs) has had a significant impact on Pd-catalyzed and Pd-mediated cross-coupling reactions. Despite their importance, widespread utility of OACs has been limited by the instability of their precursor complexes. Herein, we report
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