Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

288144

Sigma-Aldrich

Tricarbonyldichlororuthenium(II) dimer

Sinónimos:

CORM-2

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula lineal:
[Ru(CO)3Cl2]2
Número de CAS:
22594-69-0
Peso molecular:
512.01
MDL number:
MFCD00011528
UNSPSC Code:
12161600
PubChem Substance ID:
24857320
NACRES:
NA.22

Quality Level

100

reaction suitability

core: ruthenium
reagent type: catalyst

SMILES string

[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].Cl[Ru]Cl.Cl[Ru]Cl

InChI

1S/6CO.4ClH.2Ru/c6*1-2;;;;;;/h;;;;;;4*1H;;/q;;;;;;;;;;2*+2/p-4

InChI key

JYHHJVKGDCZCCL-UHFFFAOYSA-J

Application

Carbon monoxide-releasing molecule used for pharamological studies including:
  • Enhancement of coagulation and attenuation of vulnerability to fibrinolysis
  • Investigations of P2X4 as a possible target
  • Possible modification of thrombus growth or disintegration
  • Enhances fibrinogen as a substrate for thrombin
  • Regulation of ion transport by gasotransmitters

Used as a CO donor for reactive oxygen species mediated bacterial killing
Tricarbonyldichlororuthenium(II) dimer can be used in the deuteration reaction for labeling secondary amines. It can also be used for the synthesis of racemization catalysts by reacting with cyclopenta[l]phenanthrenyl and cyclopenta[a]acenaphthylenyl ligands.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
MKCR0080
MKCN3020
MKCG1927
MKCD8365
MKCB0224V

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Vance G Nielsen et al.
International journal of molecular sciences, 21(6) (2020-03-22)
Using thrombelastography to gain mechanistic insights, recent investigations have identified enzymes and compounds in Naja and Crotalus species' neurotoxic venoms that are anticoagulant in nature. The neurotoxic venoms of the four extant species of Dendroaspis (the Black and green mambas)
Cyclopenta [l] phenanthrenyl and Cyclopenta [a] acenaphthylenyl Half-Sandwich Complexes of Ruthenium as Racemization Catalysts for Secondary Alcohols.
Mavrynsky D, et al.
Organometallics, 28(2), 598-605 (2008)
One-step exchange-labelling of piperidines, piperazines and dialkylamines with deuterium oxide: catalysis by various ruthenium complexes.
Alexakis E, et al.
Tetrahedron Letters, 46(25), 4291-4293 (2005)
Po-Min Yang et al.
Vascular pharmacology, 87, 209-218 (2016-10-11)
The production of nitric oxide (NO) by endothelial NO synthase (eNOS) plays a major role in maintaining vascular homeostasis. This study elucidated the potential role of carbon monoxide (CO)-releasing molecules (CORMs) in NO production and explored the underlying mechanisms in
Vance G Nielsen et al.
Basic & clinical pharmacology & toxicology, 122(1), 157-164 (2017-07-12)
Several in vitro investigations have demonstrated that anticoagulant effects of fibrinogenolytic snake venom metalloproteinases have been abrogated in human plasma by modifying fibrinogen with iron (Fe) and carbon monoxide (CO) to prevent catalysis or by directly inhibiting these enzymes with CO.
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico