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202509

Sigma-Aldrich

Poly(ethylene glycol) methyl ether

average Mn 2,000, methoxy, hydroxyl

Sinónimos:

Polyethylene glycol monomethyl ether

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About This Item

Fórmula lineal:
CH3(OCH2CH2)nOH
Número de CAS:
9004-74-4
Número MDL:
MFCD00084416
Código UNSPSC:
12162002
ID de la sustancia en PubChem:
24852095
NACRES:
NA.23

Nombre del producto

Poly(ethylene glycol) methyl ether, average Mn ~2,000

densidad de vapor

>1 (vs air)

presión de vapor

0.05 mmHg ( 20 °C)

Formulario

flakes (or pellets)

mol peso

average Mn ~2,000

viscosidad

54.6 cSt(210 °F)(lit.)

temperatura de transición

Tm 52 °C

grupo funcional

hydroxyl

cadena SMILES

O(CCO)C

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

Clave InChI

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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Descripción general

It is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether. Etherification of the PEG chain ends can be undertaken in basic conditions by reacting it with alkyl halides. mPEG can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.

Aplicación

Poly(ethylene glycol) methyl ether-attached dendrimers can be used as carriers for anticancer drugs. This novel drug carrier has a biocompatible surface and an interior for the encapsulation of drugs.

It can be used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.

It can also be used as a starting material in the preparation of a biodegradable amphiphilic copolymer of poly(L-alanine) with mPEG.

Características y beneficios

Inserting poly(ethylene glycol) methyl ether (mPEG) side chain enhances the hydrophilicity and flexibility of the polymer matrix.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

359.6 °F - closed cup

Punto de inflamabilidad (°C)

182 °C - closed cup

Equipo de protección personal

Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000197564
0000197564
0000338361
MKCV6083
MKCV5829

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Yi Wei et al.
Langmuir : the ACS journal of surfaces and colloids, 28(39), 13984-13992 (2012-09-04)
The microcosmic mechanisms of protein (recombinant human growth hormone, rhGH) incomplete release and stability from amphiphilic poly(monomethoxypolyethylene glycol-co-D,L-lactide) (mPEG-PLA, PELA) microspheres were investigated. PELA with different hydrophilicities (PELA-1, PELA-2, and PELA-3) based on various ratios of mPEG to PLA were
Junhwa Shin et al.
Molecular pharmaceutics, 9(11), 3266-3276 (2012-10-04)
A family of 3-methoxypoly(ethylene glycol)-vinyl ether-1,2-dioleylglycerol (mPEG-VE-DOG) lipopolymer conjugates, designed on the basis of DFT calculations to possess a wide range of proton affinities, was synthesized and tested for their hydrolysis kinetics in neutral and acidic buffers. Extruded ∼100 nm
Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in
Pengxiang Zhao et al.
Chemical communications (Cambridge, England), 49(31), 3218-3220 (2013-03-14)
"Click" chemistry now offers access to a great variety of triazoles, and the first example of a strategy to stabilize gold nanoparticles (AuNPs) with a new 1,2,3-triazole-mPEG ligand is developed here together with preliminary examples of possible applications.
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
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