Skip to Content
Merck
All Photos(4)

Key Documents

View All Documentation

P4562

Sigma-Aldrich

Sodium pyruvate

powder, BioXtra, suitable for mouse embryo cell culture

Synonym(s):

α-Ketopropionic acid sodium salt, 2-Oxopropanoic acid sodium salt, Pyruvic acid sodium salt

Sign Into View Organizational & Contract Pricing
All Photos(4)

About This Item

Linear Formula:
CH3COCOONa
CAS Number:
113-24-6
Molecular Weight:
110.04
Beilstein:
3568341
EC Number:
204-024-4
MDL number:
MFCD00002586
UNSPSC Code:
12352207
PubChem Substance ID:
24898552
NACRES:
NA.75

product line

BioXtra

Assay

≥99%

form

powder

technique(s)

cell culture | embryo: suitable

mp

>300 °C (lit.)

solubility

H2O: 100 mg/mL

storage temp.

2-8°C

SMILES string

[Na+].CC(=O)C([O-])=O

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

InChI key

DAEPDZWVDSPTHF-UHFFFAOYSA-M

Looking for similar products? Visit Product Comparison Guide

General description

Pyruvate, the end-product of the glycolysis pathway, is the anion of pyruvic acid.

Application

Sodium pyruvate has been used:
  • as a supplement in Ca2+ + N-Tris(hydroxymethil)methyl-2-aminoethanesulfonic acid (TES)–NaCl medium for sperm incubation
  • as a supplement in TCM-199 hepes modification solution for cumulus-oocytes complexes (COC′s) culture
  • as a supplement in Dulbecco′s modified Eagle medium (DMEM) to culture mouse primary hepatocytes (MPHs) and also to intraperitoneally inject fasted mice for glucose production assessment

Biochem/physiol Actions

Sodium pyruvate is mainly used as a constituent in culture broth and media. It exhibits anti-oxidation and anti-inflammatory properties. Hence sodium pyruvate is considered a possible therapy for allergic rhinitis. Sodium pyruvate might also be a new approach treating lactic acidosis.
Sodium pyruvate is used by cells as an easily accessible carbohydrate source. Additionally, it is involved with amino acid metabolism and initiates the Kreb′s cycle. Sodium pyruvate attenuates oxidative stress in vitro. The 100 mM solution should be diluted at 1:100 for most cell culture applications. This product has been qualified for use in mouse embryo cultures.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1B

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

In vitro maturation of caprine oocytes in different concentrations of estrous goat serum
Kharche SD, et al.
Small Ruminant Research (2006)
Kyle S McCommis et al.
The Biochemical journal, 466(3), 443-454 (2015-03-10)
Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely
L S Li et al.
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 31(2), 103-106 (2017-01-20)
Objective:Pyruvate is a key intermediate in several metabolic pathways of human body Sodium pyruvate possesses anti-oxidation and anti-inflammatory effects, which make it a possible novel therapy for allergic rhinitis. However, the relevant clinical research is rare. The aim of the
Jing Yang et al.
Artificial cells, nanomedicine, and biotechnology, 44(1), 48-55 (2014-04-05)
To examine the effects of sodium pyruvate (SP) on metabolic acidosis. For the in vivo experiments, we evaluated effects of SP on an ammonium chloride (NH4Cl)-induced hyperchloremic acidosis rat model. SP was infused at overall doses of 2, 4, and
Maheul Ploton et al.
Journal of hepatology, 69(5), 1099-1109 (2018-07-08)
Embedded into a complex signaling network that coordinates glucose uptake, usage and production, the nuclear bile acid receptor FXR is expressed in several glucose-processing organs including the liver. Hepatic gluconeogenesis is controlled through allosteric regulation of gluconeogenic enzymes and by
View All Related Papers

Articles

Ultrapure Water for BPA-free Culture Media

Ultrapure water from Milli-Q® system shown free of BPA, suitable for embryology research, minimizing endocrine disruptor interference.

Ultrapure Water for BPA-free Culture Media

Ultrapure water from Milli-Q® system shown free of BPA, suitable for embryology research, minimizing endocrine disruptor interference.

Ultrapure Water for BPA-free Culture Media

Ultrapure water from Milli-Q® system shown free of BPA, suitable for embryology research, minimizing endocrine disruptor interference.

Ultrapure Water for BPA-free Culture Media

Ultrapure water from Milli-Q® system shown free of BPA, suitable for embryology research, minimizing endocrine disruptor interference.

See All

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service