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GW20031F

Sigma-Aldrich

Anti-Leptin antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

manufacturer/tradename

Genway 15-288-20031F

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LEP(3952)

Immunogen

Immunogen Sequence: GI # 4557715, sequence 1-167
Recombinant leptin

Application

Anti-Leptin antibody produced in chicken has been used for the immunohistochemistry study of mouse embryo and ovum. It is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.

Biochem/physiol Actions

LEP (leptin) encoded protein plays a key role in the regulation of body weight. It is secreted by white adipocytes. It has a key role in regulating the signaling pathway that can inhibit food intake and/or control energy expenditure to maintain constancy of the adipose mass. It is also involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Defects in this gene can cause a rare disease characterized by low levels of serum leptin, severe hyperphagia and severe obesity, and morbid obesity with hypogonadism.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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F F Chehab
Trends in pharmacological sciences, 21(8), 309-314 (2000-08-05)
Leptin, an adipocyte-derived hormone, informs neuroendocrine pathways about the status of energy stores in adipose tissue. The integration of this peripheral signal in hypothalamic networks results in activation of peripheral metabolic pathways that control energy build-up and expenditure. Firing of
Laura C Schulz et al.
Reproduction (Cambridge, England), 141(6), 767-777 (2011-03-30)
The hormone leptin, which is primarily produced by adipose tissue, is a critical permissive factor for multiple reproductive events in the mouse, including implantation. In the CD1 strain, maternally derived leptin from the oocyte becomes differentially distributed among the blastomeres
G Fantuzzi et al.
Journal of leukocyte biology, 68(4), 437-446 (2000-10-19)
Leptin, the product of the ob gene, is a pleiotropic molecule that regulates food intake as well as metabolic and endocrine functions. Leptin also plays a regulatory role in immunity, inflammation, and hematopoiesis. Alterations in immune and inflammatory responses are
J M Friedman et al.
Nature, 395(6704), 763-770 (1998-10-31)
The assimilation, storage and use of energy from nutrients constitute a homeostatic system that is essential for life. In vertebrates, the ability to store sufficient quantities of energy-dense triglyceride in adipose tissue allows survival during the frequent periods of food
G M Lord et al.
Nature, 394(6696), 897-901 (1998-09-11)
Nutritional deprivation suppresses immune function. The cloning of the obese gene and identification of its protein product leptin has provided fundamental insight into the hypothalamic regulation of body weight. Circulating levels of this adipocyte-derived hormone are proportional to fat mass

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