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32154

Supelco

Buparvaquone

VETRANAL®, analytical standard

Synonym(s):

2-[(4-tert-Butylcyclohexyl)methyl]-3-hydroxy-1,4-naphthoquinone, 2-[[4-(1,1-Dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedione

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About This Item

Empirical Formula (Hill Notation):
C21H26O3
CAS Number:
88426-33-9
Molecular Weight:
326.43
MDL number:
MFCD01712789
UNSPSC Code:
41116107
PubChem Substance ID:
329754074
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CC(C)(C)C1CCC(CC1)CC2=C(O)C(=O)c3ccccc3C2=O

InChI

1S/C21H26O3/c1-21(2,3)14-10-8-13(9-11-14)12-17-18(22)15-6-4-5-7-16(15)19(23)20(17)24/h4-7,13-14,24H,8-12H2,1-3H3

InChI key

KLLIVCPQDTYMLC-UHFFFAOYSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL6451
BCCJ1444
BCCJ1032
BCCG7901
BCCB5496

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Gantala Venkatesh et al.
Drug development and industrial pharmacy, 36(6), 735-745 (2010-02-09)
The aim of this study was to prepare a lipid-based self-microemulsifying drug delivery system (SMEDDS) to increase the solubility and oral bioavailability of a poorly water-soluble compound, buparvaquone (BPQ). The solubility of BPQ was determined in various vehicles, and pseudo-ternary
Juliana Q Reimão et al.
Experimental parasitology, 130(3), 195-199 (2012-01-28)
The objective of this study was to develop a novel liposomal formulation, containing phosphatidylserine (PS), of buparvaquone (BPQ) and to evaluate its in vivo effectiveness in Leishmania (L.) infantum chagasi-infected hamsters. The activity of BPQ was evaluated against both the
G R Muraguri et al.
Research in veterinary science, 81(1), 119-126 (2005-11-18)
East Coast fever, caused by the protozoan parasite Theileria parva, kills about 600,000 cattle annually in Africa. The hydroxynaphthoquinone compound buparvaquone (BPQ) is curative. Sixteen calves were infected with T. parva. On manifestation of disease symptoms, eight were injected with
Antti Mäntylä et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 23(2), 151-158 (2004-09-29)
Novel water-soluble phosphate prodrugs (2b-5b) of buparvaquone-oxime (1a) and buparvaquone-O-methyloxime (1b) were synthesized and evaluated in vitro as potential oral prodrugs against leishmaniasis. Buparvaquone-oxime (1a), and most probably also buparvaquone-O-methyloxime (1b), released the parent buparvaquone via a cytochrome P450-catalysed reaction.
Moez Mhadhbi et al.
Veterinary parasitology, 169(3-4), 241-247 (2010-02-27)
The present study describes an outbreak of tropical theileriosis cases refractory to buparvaquone treatment, which occurred in a small-size dairy farm in Tunisia. Out of seven treated cows, four died in spite of repeated buparvaquone injections (2.5 and 5 mg
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