Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

5.04905

Sigma-Aldrich

Memantine Hydrochloride

Synonym(s):

Memantine Hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride

Sign Into View Organizational & Contract Pricing

Select a Size

UNIT
$2,030.00

$2,030.00


Estimated to ship onMay 18, 2025

Validation Kit with 3 columns out of 3 different sorbent lots

To order products, please contact your local dealer.

Select a Size

Change View
UNIT
$2,030.00

About This Item

Empirical Formula (Hill Notation):
C12H21N · xHCl
CAS Number:
Molecular Weight:
179.30 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

$2,030.00


Estimated to ship onMay 18, 2025

Validation Kit with 3 columns out of 3 different sorbent lots

To order products, please contact your local dealer.

Assay

≥98% (HPLC)

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

H2O: 100 mM

storage temp.

2-8°C

SMILES string

[Cl-].[N+H3]C21CC3(CC(C2)(CC(C1)C3)C)C

InChI

1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
8.188348.21989399760
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

-

form

powder

form

powder

form

liquid

form

-

pH

2.3 (20 °C in H2O)

pH

-

pH

-

pH

-

General description

A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.

Biochem/physiol Actions

Primary Target
NMDA receptors
Target IC50: 0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255.
Anand, A., et al. 2012. Bipolar Dis.14, 64.
Lopes, P., et al. 2013. Brain and Behavior.3, 67.
Howard, R., et al. 2012. New Eng. J. Med.366, 893.
Parsons, G., et al. 1999. Neuropharmacol.38, 735.
Lee, G., et al. 2012. Psychiatry Investig.9, 166.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


  • Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

    Need A Sample COA?

    This is a sample Certificate of Analysis (COA) and may not represent a recently manufactured lot of this specific product.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service