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5.04905

Sigma-Aldrich

Memantine Hydrochloride

Synonym(s):

Memantine Hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride

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UNIT
$2,030.00

$2,030.00

Estimated to ship onMay 18, 2025

Validation Kit with 3 columns out of 3 different sorbent lots
To order products, please contact your local dealer.
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$2,030.00

About This Item

Empirical Formula (Hill Notation):
C12H21N · xHCl
CAS Number:
41100-52-1
Molecular Weight:
179.30 (free base basis)
MDL number:
MFCD00214336
UNSPSC Code:
12352200
NACRES:
NA.77

$2,030.00

Estimated to ship onMay 18, 2025

Validation Kit with 3 columns out of 3 different sorbent lots
To order products, please contact your local dealer.

Assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

H2O: 100 mM

storage temp.

2-8°C

SMILES string

[Cl-].[N+H3]C21CC3(CC(C2)(CC(C1)C3)C)C

InChI

1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H

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4,5-Difluoroanthranilic acid 97%

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Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

-

form

powder

form

powder

form

liquid

form

-

pH

2.3 (20 °C in H2O)

pH

-

pH

-

pH

-

General description

A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.

Biochem/physiol Actions

Primary Target
NMDA receptors
Target IC50: 0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255.
Anand, A., et al. 2012. Bipolar Dis.14, 64.
Lopes, P., et al. 2013. Brain and Behavior.3, 67.
Howard, R., et al. 2012. New Eng. J. Med.366, 893.
Parsons, G., et al. 1999. Neuropharmacol.38, 735.
Lee, G., et al. 2012. Psychiatry Investig.9, 166.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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