254916
7,8-Dihydroxy-6-methoxycoumarin
98%
Synonym(s):
Fraxetin
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About This Item
Empirical Formula (Hill Notation):
C10H8O5
CAS Number:
Molecular Weight:
208.17
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
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Quality Level
Assay
98%
form
powder
mp
230-231 °C (lit.)
SMILES string
COc1cc2C=CC(=O)Oc2c(O)c1O
InChI
1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3
InChI key
HAVWRBANWNTOJX-UHFFFAOYSA-N
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General description
7,8-Dihydroxy-6-methoxycoumarin is a versatile compound known for its unique fluorescence properties and its role as a photoinitiator in polymerization processes. It exhibits high reactivity under UV light, making it an ideal candidate for applications in the polymerization industry, particularly in the formulation of coatings, adhesives, and inks. It is also used in biomedical applications, such as drug delivery due to its biocompatibility.
Application
7,8-Dihydroxy-6-methoxycoumarincan be used as a UV absorber in polymer formulations. Its ability to absorbultraviolet light helps in protecting polymers from degradation caused by UVradiation, thereby improving their longevity and stability.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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María Isabel Sánchez-Reus et al.
Neuroscience research, 53(1), 48-56 (2005-07-06)
Fraxetin belongs to an extensive group of natural phenolic anti-oxidants. In the present study, using a human neuroblastoma SH-SY5Y cells, we have investigated the protective effects of this compound on modifications in endogenous reduced glutathione (GSH), intracellular oxygen species (ROS)
Po-Lin Kuo et al.
Biological & pharmaceutical bulletin, 29(1), 119-124 (2006-01-06)
Fraxetin (7,8-dihydroxy-6-methoxy coumarin), a coumarin derivative, was investigated for its effects on differentiation of osteoblasts. By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, we have shown that fraxetin exhibits a significant induction of differentiation in two human
María Francisca Molina-Jiménez et al.
Brain research, 1009(1-2), 9-16 (2004-05-04)
Rotenone-induced apoptosis is considered to contribute to the etiology of Parkinson's disease (PD). We try to prevent the apoptosis induced by rotenone toxicity with 50 microM myricetin, 100 microM fraxetin and 100 microM N-acetylcysteine (NAC) that protect against reactive oxygen
Francesco Epifano et al.
Mini reviews in medicinal chemistry, 9(11), 1262-1271 (2009-11-26)
Neurodegenerative disorders are a heterogeneous group of diseases and are among the most invaliding syndromes for humans. The aim of this manuscript is to review what has been reported so far in the literature about coumarins as a novel class
Po-Lin Kuo et al.
International immunopharmacology, 6(7), 1167-1175 (2006-05-23)
The survival of osteoblast cells is one of the determinants of the development of osteoporosis in patients with inflamed synovium, such as in rheumatoid arthritis (RA). By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, we have shown
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