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1125006

USP

Chlorpromazine hydrochloride

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

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About This Item

Fórmula empírica (notación de Hill):
C17H19ClN2S · HCl
Número de CAS:
69-09-0
Peso molecular:
355.33
Beilstein:
3779989
Número MDL:
MFCD00012654
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329749339
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

chlorpromazine

fabricante / nombre comercial

USP

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

Clave InChI

FBSMERQALIEGJT-UHFFFAOYSA-N

Información sobre el gen

human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.
Chlorpromazine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Chlorpromazine
  • Chlorpromazine Hydrochloride
  • Chlorpromazine Hydrochloride Injection
  • Chlorpromazine Hydrochloride Oral Concentrate
  • Chlorpromazine Hydrochloride Syrup
  • Chlorpromazine Hydrochloride Tablets

Acciones bioquímicas o fisiológicas

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto
Descripción
Precios

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301,H330

Clasificaciones de peligro

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Meghan J McFadden et al.
Chembiochem : a European journal of chemical biology, 15(16), 2411-2419 (2014-09-23)
Disruption of calmodulin (CaM)-based protein interactions has been touted as a potential means for modulating several disease pathways. Among these is SOX9, which is a DNA binding protein that is involved in chrondrocyte differentiation and regulation of the hormones that
Claudia Cantoni et al.
Acta neuropathologica, 129(3), 429-447 (2015-01-30)
Microglia are phagocytic cells that survey the brain and perform neuroprotective functions in response to tissue damage, but their activating receptors are largely unknown. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in
Jelle Praet et al.
NMR in biomedicine, 28(4), 505-513 (2015-03-25)
Conventional MRI is frequently used during the diagnosis of multiple sclerosis but provides only little additional pathological information. Proton MRS ((1) H-MRS), however, provides biochemical information on the lesion pathology by visualization of a spectrum of metabolites. In this study
Julie Dyall et al.
Antimicrobial agents and chemotherapy, 58(8), 4885-4893 (2014-05-21)
Outbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic with little time available for drug testing and development. Typically, clinicians are left with general supportive care and often
Hiroaki Takemoto et al.
Biological & pharmaceutical bulletin, 37(6), 1050-1055 (2014-06-03)
Dried Nardostachys chinensis roots contain sesquiterpenoids that are widely used as herbal tranquilizers. We previously identified the highly sedative sesquiterpenoid valerena-4,7(11)-diene (VLD) from this plant. In the present study, we investigated stress reducing effects of VLD and the associated mechanisms
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