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T5391

Sigma-Aldrich

Apo-transferrina human

γ-irradiated, powder, BioXtra, suitable for cell culture, ≥98%

Sinónimos:

Siderofilina, Transferrina humana

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About This Item

Número de CAS:
11096-37-0
Número CE:
234-318-8
Número MDL:
MFCD00130536
Código UNSPSC:
12352202
NACRES:
NA.75

Nivel de calidad

200

esterilidad

γ-irradiated

Línea del producto

BioXtra

Ensayo

≥98%

Formulario

powder

mol peso

76-81 kDa

concentración

~25 mM

técnicas

cell culture | mammalian: suitable

impurezas

HIV and HBsAg, source material tested negative
 iron, essentially free

solubilidad

H2O: 50 mg/mL

Nº de acceso UniProt

P02787

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... TF(7018)

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Descripción general

apo-Transferrin (aTF) human can be supplemented with iron or used to bind free iron present in media. It can be used to transport iron into mammalian cells.

Aplicación

apo-Transferrin human has been used as a supplement:
  • in Dulbecco′s modified Eagle medium/HamF12 (DMEM/F-12) to culture human adrenocortical carcinoma cells
  • in DMEM/F-12 to culture neural precursor cells from mice
  • in collecting medium NCSU23 to culture preantral follicles from porcine ovaries

Acciones bioquímicas o fisiológicas

apo-Transferrin (aTF) is an endogenous iron chelator and shows protective effects in the host by scavenging free iron and preventing the formation of toxic reactive oxygen species (ROS). It shows a therapeutic effect against thalassemia. After the release of iron, receptor-bound apo-transferrin reaches the cell surface instead of being transported to lysosomes for degradation. The cell surface has a neutral pH that promotes the release of apo-transferrin from its receptor, where it can again circulate and bind additional iron to undergo further rounds of iron delivery to cells.

Otras notas

Proteína transportadora de hierro no hemo.

Cláusula de descargo de responsabilidad

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number
0000302791
0000302791
SLCL4382
SLCD9280
SLBZ8722

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Hiroshi Kawabata
Free radical biology & medicine, 133, 46-54 (2018-07-04)
In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf-bound iron is incorporated through Tf receptor (TfR) 1-mediated endocytosis. TfR1 can mediate cellular uptake of both Tf and H-ferritin, an iron storage protein. New World arenaviruses, which cause
Miwako Yamamiya et al.
Biochemical and biophysical research communications, 513(4), 841-845 (2019-04-21)
Microglia are central nervous system-resident immune cells that play a crucial role in brain development by interacting with neural precursor cells (NPCs). It has been reported that microglia regulate the number of NPC by phagocytosis, inducing apoptosis, and promoting proliferation.
Ji Wu et al.
Journal of assisted reproduction and genetics, 24(9), 419-424 (2007-07-20)
There has been controversy over the role of FSH in the regulation of preantral follicle development. LH is a survival and differentiation factor that increases oocyte maturation in FSH-supplemented cultures of mouse preantral follicles. However, little information exists on the
Chirosree Bandyopadhyay et al.
Tissue barriers, 9(4), 1940741-1940741 (2021-08-18)
Deficits in gastrointestinal (GI) paracellular permeability has been implicated in etiology of Inflammatory Bowel Disease (IBD), and E-cadherin, a key component of the epithelial junctional complex, has been implicated in both barrier function and IBD. We have previously described antibodies
Miwako Yamamiya et al.
Biochemical and biophysical research communications, 513(4), 841-845 (2019-04-21)
Microglia are central nervous system-resident immune cells that play a crucial role in brain development by interacting with neural precursor cells (NPCs). It has been reported that microglia regulate the number of NPC by phagocytosis, inducing apoptosis, and promoting proliferation.
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