About This Item
Fórmula lineal:
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr
Número de CAS:
Peso molecular:
3741.10
UNSPSC Code:
12352200
NACRES:
NA.32
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General description
The TAT-BECLIN-1 (autophagy activator) peptide is derived from a region of the autophagy protein, beclin 1, attached to the HIV-1 Tat protein transduction domain. The peptide includes 11 amino acids at the N terminus derived from the Tat protein transduction domain, 18 amino acids (267–284 aa) from beclin 1 at the C terminus and a GG linker.
Biochem/physiol Actions
The TAT-BECLIN-1 (autophagy activator) peptide reduces the accumulation of polyglutamine aggregates and pathogen replication in vitro. This peptide is also found to reduce the mortality of mice infected by different viruses. The TAT-BECLIN-1 peptide is predicted to stimulate cell death via autophagy.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Autosis is a Na+, K+-ATPase?regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia?ischemia.
Liu Y, et al.
Proceedings of the National Academy of Sciences of the USA, 110(51), 20364-20371 (2013)
Identification of a candidate therapeutic autophagy-inducing peptide.
Shoji-Kawata S, et al.
Nature, 494(7436), 201-201 (2013)
Sangam Rajak et al.
Molecular metabolism, 53, 101286-101286 (2021-07-06)
Crinophagy is a secretory granule-specific autophagic process that regulates hormone content and secretion in endocrine cells. However, despite being one of the earliest described autophagic processes, its mechanism of action and regulation in mammalian cells remains unclear. Here, we examined
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