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T1157

Sigma-Aldrich

(+)-α-Tocopherol acetate

BioReagent, suitable for insect cell culture, ~1360 IU/g

Sinónimos:

Vitamin E acetate

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About This Item

Fórmula empírica (notación de Hill):
C31H52O3
Número de CAS:
58-95-7
Peso molecular:
472.74
Número CE:
200-405-4
Número MDL:
MFCD00072052
Código UNSPSC:
12352205
eCl@ss:
34058007
ID de la sustancia en PubChem:
24899940
NACRES:
NA.75

origen biológico

plant

Nivel de calidad

200

descripción

Synthesized from natural α-tocopherol

Línea del producto

BioReagent

Formulario

liquid (or semi-solid)

actividad específica

~1360 IU/g

mol peso

Mw 472.74 g/mol

purificado por

crystallization

técnicas

cell culture | insect: suitable

color

white to yellow

solubilidad

chloroform: soluble 50 mg/mL, clear, colorless to yellow

temp. de almacenamiento

room temp

cadena SMILES

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

Clave InChI

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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Descripción general

α-Tocopherol acetate is a semisynthetic acetate ester of naturally occurring α-tocopherol.

Aplicación

(+)-α-Tocopherol acetate has been used:
  • as a supplement in the human embryonic kidney cells (HEK 293) to assess its impact on cell growth
  • as a component of Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F12) for immortalized chondrocyte cell line
  • as a component of serum-free medium for human colon tissue organ culture
  • to test its antioxidant effects on cow articular chondrocytes

Use in insect cell culture applications as an antioxidant.

Acciones bioquímicas o fisiológicas

α-Tocopherol acetate or vitamin E-acetate has antioxidant properties and reduces lipid peroxidation. However, vitamin E acetate on pyrolysis leads to the generation of carcinogens like alkenes and benzenes.

Precaución

Since the M.P. is about 25 °C this preparation is usually an oil. Does not air oxidize.

Frases de peligro

H413

Consejos de prudencia

P273 - P501

Clasificaciones de peligro

Aquatic Chronic 4

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Equipo de protección personal

Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
SLCP3432
SLCL1318
SLCH1778
SLBZ9611
SLBZ4654

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Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments.
Laura Cervera et al.
BMC proceedings, 5 Suppl 8, P126-P126 (2012-03-01)
Role of vitamin E-acetate on cisplatin induced genotoxicity: An in vivo analysis
Mazumdar M, et al.,
Central European Journal of Biology, 7(2), 334-342 (2012)
Horst Claassen et al.
Cell and tissue research, 319(3), 439-445 (2005-01-26)
Osteoarthritis (OA) is aggravated in menopausal women possibly because of changed serum estrogen levels. Estradiol has been postulated to affect oxidative stress induced by reactive oxygen species (ROS) in articular chondrocytes. We generated ROS in cultured bovine articular chondrocytes by
Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 47(1), 32-38 (2010-11-26)
We have recently shown that a multi-mineral extract from the marine red algae, Lithothamnion calcareum, suppresses colon polyp formation and inflammation in mice. In the present study, we used intact human colon tissue in organ culture to compare responses initiated
Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 46(2), 114-122 (2009-11-17)
Normal and neoplastic human colon tissue obtained at surgery was used to establish conditions for organ culture. Optimal conditions included an atmosphere of 5% CO2 and 95% O2; tissue partially submerged with mucosa at the gas interface; and serum-free medium
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