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SML3964

Sigma-Aldrich

Methylprednisolone acetate

≥98% (HPLC)

Sinónimos:

(6α,11β)-21-(Acetyloxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione acetate, 11β,17α,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate, 21-Acetoxy-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione acetate, 6-Methylprednisolone acetate, Depo-Medro acetatel

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About This Item

Fórmula empírica (notación de Hill):
C24H32O6
Número de CAS:
53-36-1
Peso molecular:
416.51
MDL number:
MFCD00200356
UNSPSC Code:
12352200

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 85 to 105°, c = 0.5 in chloroform-d

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Long-acting anti-inflammatory corticosteroid that suppresses lymphocytes-mediated immunologic responses.



Methylprednisolone acetate (Depo-Medrol) is a long-acting anti-inflammatory corticosteroid that suppresses lymphocytes-mediated immunologic responses. 6-Methylprednisolone acetate binds to intracellular glucocorticoid receptors and inhibits promoter domains of pro-inflammatory genes and hinders secretion of inflammatory cytokines. It effectively treats multiple ailments such as rheumatic and autoimmune diseases, leukemia, multiple myeloma, and Hodgkin’s and non-Hodgkin’s lymphoma symptoms along with other drugs. MPA improves COVID-19 pneumonia prognosis.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Neda Kasiri et al.
Cell journal, 25(5), 307-316 (2023-06-10)
In spite of the advances in therapeutic modalities, morbidity, due to multiple sclerosis (MS), still remains high. Therefore, a large body of research is endeavouring to discover or develop novel therapies with improved efficacy for treating MS patients. In the
Zarah A Belacic et al.
American journal of veterinary research, 84(4) (2023-03-16)
To investigate the effects of interleukin-1β (IL-1β) and methylprednisolone acetate (MPA) on equine intrabursal deep digital flexor tendon (DDFT) and navicular bone fibrocartilage (NBF) cells in vitro. Third passage DDFT and NBF cells from 5 healthy donor horses ages 11-17
Inflammatory arthritis or osteoarthritis of the knee - Efficacy of intra-joint infiltration of methylprednisolone acetate versus triamcinolone acetonide or triamcinolone hexacetonide.
Antonio Silvinato et al.
Revista da Associacao Medica Brasileira (1992), 63(10), 827-836 (2017-12-22)

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