SML2627
Connexin43 mimetic peptide 5 trifluoroacetate salt
≥95% (HPLC)
Sinónimos:
Peptide 5 trifluoroacetate salt, VDCFLSRPTEKT trifluoroacetate salt, Val-Asp-Cys-Phe-Leu-Ser-Arg-Pro-Thr-Glu-Lys-Thr trifluoroacetate salt
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About This Item
Fórmula empírica (notación de Hill):
C60H98N16O20S · xC2HF3O2
Número de CAS:
Peso molecular:
1395.58 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
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assay
≥95% (HPLC)
form
lyophilized powder
color
white to beige
storage temp.
−20°C
Biochem/physiol Actions
Connexin43 mimetic peptide 5 is a blocker of connexin43 hemichannels that inhibits gap junction channels following CNS injury. Peptide 5 was designed to bind to extracellular regions of the connexin43 protein.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yilin Mao et al.
Experimental brain research, 235(10), 3033-3048 (2017-07-21)
Systemic administration of a Connexin43 mimetic peptide, Peptide5, has been shown to reduce secondary tissue damage and improve functional recovery after spinal cord injury (SCI). This study investigated safety measures and potential off-target effects of Peptide5 systemic administration. Rats were
Helen V Danesh-Meyer et al.
Brain : a journal of neurology, 135(Pt 2), 506-520 (2012-02-22)
Connexin43 gap junction protein is expressed in astrocytes and the vascular endothelium in the central nervous system. It is upregulated following central nervous system injury and is recognized as playing an important role in modulating the extent of damage. Studies
Yeri Kim et al.
Biochimica et biophysica acta. General subjects, 1861(2), 68-78 (2016-11-07)
Non-selective Connexin43 hemichannels contribute to secondary lesion spread. The hemichannel blocking peptidomimetic Peptide5, derived from the second extracellular loop of the human Connexin43 protein, prevents lesion spread and reduces vascular permeability in preclinical models of central nervous system injury. The
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