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Merck
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Key Documents

SML1538

Sigma-Aldrich

NMDI14

≥97% (HPLC)

Sinónimos:

4,5-Dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-3-thiophenecarboxylic acid ethyl ester, Ethyl 2-{[(6,7–dimethyl–3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate

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About This Item

Fórmula empírica (notación de Hill):
C21H25N3O4S
Número de CAS:
307519-88-6
Peso molecular:
415.51
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 0.2 mg/mL, clear (warmed)

storage temp.

2-8°C

Application

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:
  • to study its effects on differentiating cardiomyocytes
  • to study its effects on zebrafish pdzk1 gene-knockout embryos
  • to analyze its effects on the apoptosis of colorectal cancer cells

Biochem/physiol Actions

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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Michael Bordonaro et al.
Journal of Cancer, 10(2), 287-292 (2019-02-06)
Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD)
Xinyun Chen et al.
Nature communications, 12(1), 89-89 (2021-01-06)
The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Qki is found highly expressed in developing and adult hearts. By employing the human
Greg H P Ngo et al.
Nature communications, 12(1), 3849-3849 (2021-06-24)
DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks (DSBs) occurring within transcriptional active regions of the genome. The induction of DNA-RNA hybrids strongly affects the repair of these DSBs, but the nature of these structures
Jiaheng Xie et al.
Investigative ophthalmology & visual science, 62(3), 29-29 (2021-03-23)
The human PDZK1 gene is located in a genomic susceptibility region for neurodevelopmental disorders. A genome-wide association study identified links between PDZK1 polymorphisms and altered visual contrast sensitivity, an endophenotype for schizophrenia and autism spectrum disorder. The PDZK1 protein is

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