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SML0772

Sigma-Aldrich

Curvularin

from Penicillium citrinum, ≥98% (HPLC)

Sinónimos:

2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-

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About This Item

Fórmula empírica (notación de Hill):
C16H20O5
Número de CAS:
10140-70-2
Peso molecular:
292.33
MDL number:
MFCD09752718
UNSPSC Code:
51111800
PubChem Substance ID:
329825596
NACRES:
NA.77

biological source

Penicillium citrinum

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

DMSO: 1 mg/mL

storage temp.

−20°C

SMILES string

OC1=C(C(CCCCC[C@H](C)O2)=O)C(CC2=O)=CC(O)=C1

InChI

1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3/t10-/m0/s1

InChI key

VDUIGYAPSXCJFC-JTQLQIEISA-N

Biochem/physiol Actions

S - Curvularin is a macrocyclic lactone with cytotoxic activity. Curvularin inhibits cell division as well as expression of human inducible nitric oxide synthase (iNOS), an enzyme critically involved in pro-inflammatory immune processes. Curvularin anti-inflammatory activity was demonstrated in chronic inflammatory disease models in mice such as Chronic Induced Arthritis (CIA) as well as in human alveolar epithelial A549/8 cells.

Reconstitution

Soluble in DMSO (1 mg/mL), Chloroform (3 mg/mL) and Dichloromethane (3 mg/mL). Note: Insoluble in water.

Other Notes

Store the product sealed at −20 °C. Under these conditions the product is stable for at least 5 years.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
32140502
104M4079V
14140527
32140501

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Birgitte Andersen et al.
International journal of food microbiology, 126(1-2), 172-179 (2008-07-05)
Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agents. Ulocladium spp. are often found on dead vegetation, in soil, air and
Lian Wu Xie et al.
Applied biochemistry and biotechnology, 159(1), 284-293 (2009-04-01)
With the anti-microbial and anti-tumor composite screening model, bioassay-guided fractionation led to the isolation of two structurally related bioactive compounds, curvularin and alphabeta-dehydrocurvularin, from ethyl acetate extract of Eupenicillium sp. associated with marine sponge Axinella sp. Further study on the
Kristina Rudolph et al.
Cytokine, 61(1), 285-296 (2012-11-09)
TGF-β is a multifunctional cytokine that regulates cell proliferation, differentiation, apoptosis and extracellular matrix production. Deregulation of TGF-β production or signaling plays a pivotal role in a variety of pathological processes such as cancer, metastasis, angiogenesis and fibrosis. Therefore, TGF-β
Ia I Savchuk et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 74(4), 52-56 (2012-10-24)
Silica gel column chromatography (silica gel "L" II kind of activity 100/160 mkm) of the chloroform extract from the cultural filtrate of Penicillium sp. 10-51 gave two fractions (chloroform and chloroform-acetone, 5:1) having biological activity. Recrystallization yielded two compounds. On
Nadine Schmidt et al.
Biochemical pharmacology, 79(5), 722-732 (2009-10-27)
Chondrocytes are important for the development and maintenance of articular cartilage. However, both in osteoarthritis (OA) and rheumatoid arthritis (RA) chondrocytes are involved in the process of cartilage degradation and synthesize important immunomodulatory mediators, including nitric oxide (NO) generated by
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