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Key Documents

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SML0424

Sigma-Aldrich

ST247

≥98% (HPLC)

Sinónimos:

3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester

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About This Item

Fórmula empírica (notación de Hill):
C19H26N2O5S2
Número de CAS:
1356497-91-0
Peso molecular:
426.55
UNSPSC Code:
12352200
PubChem Substance ID:
329825419
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

CCCCCCNc1ccc(NS(=O)(=O)c2ccsc2C(=O)OC)c(OC)c1

InChI

1S/C19H26N2O5S2/c1-4-5-6-7-11-20-14-8-9-15(16(13-14)25-2)21-28(23,24)17-10-12-27-18(17)19(22)26-3/h8-10,12-13,20-21H,4-7,11H2,1-3H3

InChI key

MRWCGEOYGFZZCJ-UHFFFAOYSA-N

Biochem/physiol Actions

ST247 is a PPAR β/δ selective inverse agonist. The compound is based on the structure of GSK0660, and is 10-fold more potent in blocking the transcription of endogenous target genes: ST247 IC50 = 19 nm vs. GSK0660 IC50 = 210 nM.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Artículos

Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

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