SML0409

STF-083010

≥98% (HPLC)

• Sinónimos: N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
• Fórmula empírica (notación de Hill): C₁₅H₁₁NO₃S₂
• Número de CAS: 307543-71-1
• Peso molecular: 317.38
• Número MDL: MFCD02332975
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825404
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: light yellow to yellow-green
• solubilidad: DMSO: 5 mg/mL (clear solution)
• temp. de almacenamiento: −20°C
• cadena SMILES: OC1=C(/C=N/S(C2=CC=CS2)(=O)=O)C3=C(C=CC=C3)C=C1
• InChI: 1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
• Clave InChI: TVIVJHZHPKNDAQ-MHWRWJLKSA-N

Descripción

Aplicación

STF-083010 has been used:

• in a study to investigate the potential anti-lipotoxic effect of nicotinamide and to elucidate underlying mechanism(s)
• as IRE1a inhibitor to study its effect on NOS 2 expression and investigate the underlying mechanisms in proinflammatory gene expression in astrocytes
• to block endogenous XBP1 cleavage for one hour prior to palmitate exposure in order to examine whether inositol?requiring enzyme 1α (IRE1α ) activation is implicated in palmitate cytotoxicity

Acciones bioquímicas o fisiológicas

STF-083010 is a potent inhibitor of IRE-1 mRNA splicing activity.

STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. STF-083010 inhibits IRE1 endonuclease and mRNA splicing activity in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable