SML0097

Nevirapine

• Sinónimos: 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one
• Fórmula empírica (notación de Hill): C₁₅H₁₄N₄O
• Número de CAS: 129618-40-2
• Peso molecular: 266.30
• Número MDL: MFCD00866928
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825155
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Nivel de calidad: 100
• Formulario: powder
• color: white to tan
• solubilidad: DMSO: ≥22 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
• InChI: 1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
• Clave InChI: NQDJXKOVJZTUJA-UHFFFAOYSA-N

Descripción

Aplicación

Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs).

Acciones bioquímicas o fisiológicas

NNRTI (non-nucleoside reverse transcriptase inhibitor) of HIV-1

Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome.

Nevirapine is an allosteric, non-nucleoside inhibitor of HIV reverse transcriptase (NNRTI). The K_i for inhibition of wild-type RT by Nevirapine is 200 nM.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable