SCP0157
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP)
Sinónimos:
GRGDSP Peptide, RGD Peptide
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About This Item
Productos recomendados
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥60%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
Gly-Arg-Gly-Asp-Ser-Pro
General description
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is a bioactive molecule/peptide derived from fibronectin.
Application
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) has been used:
- in coating well plate to monitor cell attachment by crystal violet staining
- to treat baby hamster kidney (BHK-21) cells to study the role of Arg-Gly-Asp (RGD) motif in the replication of Japanese encephalitis virus (JEV)
- to block RGD-dependent integrins or integrin signaling in INA-6 cells
- to study the role of the RGD-binding integrins in Gal-3-mediated cell adhesion
Biochem/physiol Actions
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can stimulate endothelialization by modifying the surface of cardiovascular implants. The major cell- binding domain of GRGDSP helps to promote cell adhesion on a wide range of substrates.
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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Journal of biomedical materials research. Part A, 83(2), 423-433 (2007-04-25)
Vascular endothelium plays an important role in preventing thrombogenesis. Bioactive molecules such as fibronectin-derived peptide Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization. Here we conjugated GRGDSP peptide to
Research in veterinary science, 111, 67-74 (2017-01-04)
Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that is one of the major causes of viral encephalitis diseases worldwide. The JEV envelope protein facilitates viral entry, and its domain III contains an Arg-Gly-Asp (RGD) motif, that may modulate JEV
Acta biomaterialia, 62, 317-327 (2017-09-03)
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International journal of molecular sciences, 22(10) (2021-06-03)
Galectin-3 (Gal-3) is a β-galactoside-binding protein that influences various cell functions, including cell adhesion. We focused on the role of Gal-3 as an extracellular ligand mediating cell-matrix adhesion. We used human adipose tissue-derived stem cells and human umbilical vein endothelial
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