Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

SAE0112

Sigma-Aldrich

β2-Microglobulin from human urine

≥98% (SDS-PAGE), solution

Sinónimos:

β2-Microglobulin from human urine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

MDL number:
MFCD00130615
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

assay

≥98% (SDS-PAGE)

form

solution

impurities

Infectious Agents, tested

solubility

water: soluble

UniProt accession no.

P61769

storage temp.

2-8°C

Gene Information

human ... B2M(567)

¿Está buscando productos similares? Visita Guía de comparación de productos

General description

Research area: Cancer

β2 microglobulin (β2-M) is a polypeptide that associates with the heavy chain of class I major histocompatibility complex (MHC) antigens on the cell surface. It is a non-glycosylated protein, synthesized by all nucleated cells. Its secondary structure comprises of seven β-strands, arranged into two β-sheets connected by a single disulfide bridge.

Application

β2-Microglobulin from human urine was used to test humoral CSF parameters in the differential diagnosis of hematologic CNS neoplasia. It was also used in the identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.

Biochem/physiol Actions

The interaction of β2 microglobulin (β2-M) with major histocompatibility complex (MHC) is dynamic and plays a critical role in the stability of the MHC antigens and their ability to present peptide antigens in CD8+ cells. A transient complex of MHC heavy chain and β2-M is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-M complex to the cell surface. Absence of binding leads to degradation in the proteasome. β2-M serves as a regulator of cell survival, proliferation, migration, invasion, apoptosis, angiogenesis, and metastasis in cancer cells. It is also recognized for promoting the growth and survival of stromal cells, such as mesenchymal stem cells (MSCs), osteoblasts, and osteoclasts, thereby supporting cancer bone metastasis.

Preparation Note

Prepared by the method of Berggard and Bearn.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

?2-Microglobulin: emerging as a promising cancer therapeutic target
Shi C, et al.
Drug Discovery Today, 14(1-2), 25-30 (2009)
?2-Microglobulin-mediated Signaling as a Target for Cancer Therapy
Nomura T, et al.
Anticancer Agents in Medicinal Chemistry, 14(3), 343?352-343?352 (2014)
The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator
Li L, et al.
Chinese Medical Journal (English Edition), 129(4), 448-455 (2016)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico