SAB5702250

Anti-CLDN18.2 Antibody, clone 3J4G7, Rabbit Monoclonal

• Sinónimos: CLDN18,SFTA5,SFTPJ
• UNSPSC Code: 12352203
• NACRES: NA.46

Propiedades

• biological source: rabbit
• Quality Level: 100
• material: colorless
• clone: 3J4G7, monoclonal
• form: liquid
• species reactivity: human
• concentration: 1.191 mg/mL
• technique(s): immunohistochemistry: 1:50 - 1:200
• color: colorless
• isotype: IgG
• UniProt accession no.: P56856
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CLDN18.2(51208)

Descripción

General description

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Immunogen

A synthetic peptide of human CLDN18.2.

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

Application

IHC

Información de seguridad

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H317,H411
• pcodes: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Hazard Classifications: Aquatic Chronic 2 - Skin Sens. 1
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3