SAB5700359

Anti-Phospho-STAT6-Y641 antibody produced in rabbit

• Sinónimos: D12S1644, IL-4-STAT, STAT6, STAT6B, STAT6C
• UNSPSC Code: 12352203
• NACRES: NA.43

Propiedades

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 74; 81; 94
• species reactivity: human
• concentration: 1.42 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: P42226
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr641)
• Gene Information: human ... STAT6(6778)

Descripción

General description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Immunogen

A phospho specific peptide corresponding to residues surrounding Y641 of human STAT6

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable