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SAB4300670

Sigma-Aldrich

Anti-phospho-SP1 (pThr739) antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Anti-Sp1 transcription factor, Anti-TSFP1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

mol peso

~90 kDa

reactividad de especies

human, mouse, rat

concentración

1 mg/mL

técnicas

western blot: 1:500-1:1000

isotipo

IgG

secuencia del inmunógeno

(T-A-Tp-P-S)

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

phosphorylation (pThr739)

Información sobre el gen

human ... SP1(6667)

Descripción general

Specific protein 1 (Sp1) is a transcription regulator that has a transactivation domain at the N-terminus and a DNA-binding domain at the C-terminus, that contain three zinc fingers (ZF). It belongs to transcription factor family and is located on chromosome 12q13.

Inmunógeno

Peptide sequence around phosphorylation site of threonine 739 (T-A-Tp-P-S), according to the protein NP_612482.2

Aplicación

Anti-phospho-SP1 (pThr739) antibody has been used in immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Acciones bioquímicas o fisiológicas

Specific protein 1 (Sp1) controls the up- and down-regulation of hCtr1 (human high-affinity copper transporter 1). It controls the expression of several genes that participates in differentiation, cell cycle and oncogenesis. It has the ability to bind GC/GT‐rich promoter elements with the help of C(2)H(2)‐type zinc fingers at the C‐terminal domain.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descripción de destino

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Effects of Cu(II) and cisplatin on the stability of Specific protein 1 (Sp1)-DNA binding: Insights into the regulation of copper homeostasis and platinum drug transport
Yan D, et al.
Journal of Inorganic Biochemistry (2016)
MiR-24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1
Kang M, et al.
Cancer Medicine (2016)
An insight into the phylogenetic history of HOX linked gene families in vertebrates
Abbasi AA and Grzeschik KH
BMC Evolutionary Biology (2007)
Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia
Grell AS, et al.
PLoS ONE (2014)
Anne-Sofie Grell et al.
PloS one, 9(12), e113624-e113624 (2014-12-06)
Increased expression of endothelin receptor type B (ETBR), a vasoactive receptor, has recently been implied in the reduced cerebral blood flow and exacerbated neuronal damage after ischemia-reperfusion (I/R). The study explores the regulatory mechanisms of ETBR to identify drug targets

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