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SAB2500845

Sigma-Aldrich

Anti-Pyruvate Carboxylase antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-PCB

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

goat

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

reactividad de especies

mouse, human, rat, canine, pig, bovine

técnicas

indirect ELISA: suitable
western blot: suitable

Nº de acceso UniProt

P11498

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... PC(5091)

Descripción general

Pyruvate carboxylase (PC), a mitochondrial enzyme, is a nuclear-encoded protein. Expression of biologically active PC is seen in skeletal muscle. PC is a homotetramer in vertebrates, with each subunit having biotin carboxylase (BC), carboxyltransferase (CT), and biotin-carboxyl carrier protein (BCCP) domains and a covalently linked biotin cofactor. The PC gene is located on human chromosome 11q13.2.

Inmunógeno

Peptide with sequence C-KFKEVKKAYVEANQ from the internal region of the protein sequence according to NP_000911.2; NP_001035806.1; NP_071504.2.

Aplicación

Anti-Pyruvate Carboxylase antibody produced in goat has been used in immunoblotting.

Acciones bioquímicas o fisiológicas

Pyruvate carboxylase (PC) enzyme converts pyruvate to oxaloacetate. It plays an important role in mitochondrial metabolism in all cells and its absence is lethal. Expression of PC is highly essential for the development of pulmonary tumors. PC is involved in the pulmonary tropism of metastatic breast cancer. It is associated with the pathogenesis of ovarian cancer. Lower expression of PC can block cell proliferation, progression of the cell cycle, migration, and invasion of cells.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
8310P1

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Visite la Librería de documentos

Arun Nandwani et al.
Redox biology, 69, 102989-102989 (2023-12-16)
Inspite of exerting independent cellular functions, the endoplasmic-reticulum (ER) and the mitochondria also physically connect at specific sites termed mitochondria-associated ER membranes (MAMs) and these sites consist of several tethering proteins that play varied roles in diverse cellular processes. However
Hongkai Shang et al.
Aging, 12(21), 21874-21889 (2020-11-13)
The aim of this study was to explore prognosis-related biomarkers and underlying mechanisms during ovarian carcinoma progression and development. mRNA expression profiles and GSE49997 dataset were downloaded. Survival analyses were performed for genes with high expression levels. Expression level of
Ariane D Minet et al.
Biochemical and biophysical research communications, 402(2), 196-197 (2010-09-03)
Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates. The presence of PC in skeletal muscle is controversial. We report here, that PC protein is easily
Mukul K Midha et al.
Journal of proteome research, 11(12), 6030-6043 (2012-10-12)
Molecular mechanism governing biological processes leading to dietary obesity and diabetes are largely unknown. Here we study the liver proteome differentially expressed in a long-term high-fat and high-sucrose diet (HFHSD)-induced obesity and diabetes mouse model. Changes in mouse liver proteins
Aparna Shinde et al.
Breast cancer research : BCR, 20(1), 76-76 (2018-07-15)
Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression. Disseminated tumor cells encounter major changes in nutrient supplies and oxidative stresses compared to the primary tumor and must demonstrate
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