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RAB0458

Sigma-Aldrich

Human Thyroglobulin ELISA Kit

for serum, plasma, cell culture supernatants and urine

Sinónimos:

TGF-beta-1, Thyroglobulin

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.77

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type urine
sample type plasma
sample type cell culture supernatant(s)
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 220 pg/mL
standard curve range: 0.205-50 ng/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TG(7038)

General description

The Human Thyroglobulin ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Thyroglobulin in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Human Thyroglobulin

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human Thyroglobulin ELISA Kit has been used to measure the secreted thyroglobulin (TG) level in primary human thyrocytes.

Biochem/physiol Actions

Thyroglobulin (TG) is a prothyroid hormone. It plays a vital role in production of L-thyroxine (tetraiodothyronine, T4) and L-triiodothyronine (T3) hormones in thyroid gland. Tyrosyls of TG acts as substrate for iodination and hormone formation. Serum thyroglobulin level is used as marker of metastases in differentiated thyroid carcinomas. Mutation in the gene is associated with the development of congenital goitrous hypothyroidism and non-endemic simple goitre.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Los componentes del kit también están disponibles por separado

Referencia del producto
Descripción
SDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)SDS
  • RABELADCELISA 1X Assay/Sample Diluent Buffer C (Item L)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Sarah J Morgan et al.
Thyroid : official journal of the American Thyroid Association, 26(12), 1794-1803 (2016-10-19)
Major regulation of thyroid gland function is mediated by thyrotropin (TSH) activating the TSH receptor (TSHR) and inducing upregulation of genes involved in thyroid hormone synthesis. Evidence suggests that the insulin-like growth factor 1 (IGF-1) receptor (IGF-1R) may play a
Yuwei Wang et al.
Ecotoxicology and environmental safety, 174, 224-235 (2019-03-08)
In recent years, decabromodiphenyl ethane (DBDPE), a new alternative flame retardant to the decabrominated diphenyl ethers (BDE-209), is widely used in a variety of products. Previous studies have indicated that DBDPE, like BDE-209, could disrupt thyroid function. However, compared with
Daesong Jang et al.
Thyroid : official journal of the American Thyroid Association, 30(2), 270-276 (2019-12-07)
Background: Thyrotropin (TSH) and thyroid-stimulating antibodies (TSAbs) activate TSH receptor (TSHR) signaling by binding to its extracellular domain. TSHR
Kathleen M Aicher et al.
PloS one, 14(2), e0212638-e0212638 (2019-02-28)
Gallbladder mucocele formation is an emerging disease in dogs characterized by increased secretion of condensed granules of gel-forming mucin by the gallbladder epithelium and formation of an abnormally thick mucus that can culminate in obstruction of the bile duct or
A nonsense mutation causes human hereditary congenital goiter with preferential production of a 171-nucleotide-deleted thyroglobulin ribonucleic acid messenger.
Targovnik H M, et al.
The Journal of Clinical Endocrinology and Metabolism, 77(1), 210-215 (1993)
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