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PZ0135

Sigma-Aldrich

PHA-543613

≥98% (HPLC)

Sinónimos:

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide

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About This Item

Fórmula empírica (notación de Hill):
C15H17N3O2
Número de CAS:
478149-53-0
Peso molecular:
271.31
Código UNSPSC:
51111800
ID de la sustancia en PubChem:
329823720
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to off-white

solubilidad

DMSO: ≥20 mg/mL

temp. de almacenamiento

room temp

cadena SMILES

O=C(N[C@H]1CN2CC[C@H]1CC2)c3cc4ccoc4cn3

InChI

1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1

Clave InChI

IPKZCLGGYKRDES-ZDUSSCGKSA-N

Información sobre el gen

human ... CHRNA7(1139)

Aplicación

PHA-543613 has been used to study its effect on recognition memory and neurovascular coupling (NVC) response in β-amyloid (Aβ) 25-35-treated mice.[1] It has also been used to study its effect on Aβ25-35-induced receptor alteration and cognitive impairment in mice.[2]

Acciones bioquímicas o fisiológicas

PHA-543613 exhibits rapid brain penetration property.[1]
PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer′s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays.
PHA-543613 is a potent selective a7 nAChR agonist.

Características y beneficios

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000154474
0000154474
0000132276
0000057539
0000057538

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Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function
Sadigh-Eteghad S, et al.
Acta Cirurgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa em Cirurgia, 30(11), 736-742 (2015)
Mark R Albertini et al.
Environmental and molecular mutagenesis, 49(9), 676-687 (2008-08-21)
The identification of specific lymphocyte populations that mediate tumor immune responses is required for elucidating the mechanisms underlying these responses and facilitating therapeutic interventions in humans with cancer. To this end, mutant hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficient (HPRT-) T-cells were used
Stefan M Gold et al.
Journal of neuroinflammation, 5, 32-32 (2008-08-02)
Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a pronounced neurodegenerative component. It has been suggested that novel treatment options are needed that target both aspects of the disease. Evidence from basic and clinical studies
Selective activation of $\alpha$7 nicotinic acetylcholine receptor by PHA-543613 improves A$\beta$25--35-mediated cognitive deficits in mice
Sadigh-Eteghad S, et al.
Neuroscience, 298(11), 81-93 (2015)
Evhy Apryani et al.
Journal of neuroinflammation, 17(1), 75-75 (2020-03-03)
Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for the treatment of chronic pain especially cancer pain. The current study aimed to evaluate its antinociceptive effects in bone cancer pain and explore the underlying
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