P8390

Picrotoxinin

• Fórmula empírica (notación de Hill): C₁₅H₁₆O₆
• Número de CAS: 17617-45-7
• Peso molecular: 292.28
• MDL number: MFCD00078765
• UNSPSC Code: 41116107
• PubChem Substance ID: 24898746
• NACRES: NA.77

Propiedades

• form: powder
• SMILES string: [H][C@@]12OC(=O)[C@]([H])([C@@H]1C(C)=C)[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@@]2([H])[C@]35C
• InChI: 1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8+,9-,10-,13-,14-,15+/m1/s1
• InChI key: PIMZUZSSNYHVCU-KBLUICEQSA-N

Descripción

General description

Picrotoxinin is a component of picrotoxin and can be derived from plants. It is a non-nitrogenous compound.

Application

Picrotoxinin has been used as an agonist of taste 2 receptor member 14 (TAS2R14) to perform an array-based bitter receptor screening assay and to study the effect of calcium buffering and calcium sensor type on its sensitivity.

Biochem/physiol Actions

Picrotoxinin acts as a potent convulsant.

GABA_A receptor antagonist; binds to the GABA receptor-linked Cl⁻ channel.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glycine Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Active component of picrotoxin

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges