P7791

Prazosin hydrochloride

≥99.0% (HPLC), powder, α1-adrenoceptor antagonist

• Sinónimos: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride
• Fórmula empírica (notación de Hill): C₁₉H₂₁N₅O₄ · HCl
• Número de CAS: 19237-84-4
• Peso molecular: 419.86
• Beilstein: 4303561
• Número CE: 242-903-4
• Número MDL: MFCD00058177
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277793
• NACRES: NA.77

Propiedades

• Nombre del producto: Prazosin hydrochloride, ≥99.0% (HPLC)
• Nivel de calidad: 100
• Ensayo: ≥99.0% (HPLC)
• Formulario: powder
• solubilidad: H₂O: 0.5 mg/mL; methanol: 6 mg/mL; dilute aqueous acid: insoluble
• cadena SMILES: Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
• InChI: 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
• Clave InChI: WFXFYZULCQKPIP-UHFFFAOYSA-N
• Información sobre el gen: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Descripción

Descripción general

Prazosin is a member of the class of α-adrenergic blockers.[1] It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.[2]

Aplicación

Prazosin hydrochloride has been used:

• to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice[3]
• as an α1-adrenoceptor blocker,administered intragastrically in rats[4]
• as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions[5]

Acciones bioquímicas o fisiológicas

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD).[6] It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.[1]

Características y beneficios

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Precaución

Hygroscopic; light sensitive.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Warning
• Frases de peligro: H336,H361fd,H373
• Consejos de prudencia: P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313
• Clasificaciones de peligro: Repr. 2 - STOT RE 2 - STOT SE 3
• Órganos de actuación: Central nervous system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves