P1645

Palmitoyl-L-carnitine chloride

≥98% (TLC), powder

• Sinónimos: O-Palmitoyl-L-carnitine chloride
• Fórmula lineal: C₂₃H₄₆NO₄ · Cl
• Número de CAS: 18877-64-0
• Peso molecular: 436.07
• Beilstein: 4071005
• Número CE: 242-642-6
• Número MDL: MFCD00070346
• Código UNSPSC: 12352211
• ID de la sustancia en PubChem: 24898229
• NACRES: NA.25

Propiedades

• Nivel de calidad: 200
• Ensayo: ≥98% (TLC)
• Formulario: powder
• color: white
• solubilidad: H₂O: 25 mg/mL (with heat or sonication)
• tipo de lípido: saturated FAs
• temp. de almacenamiento: −20°C
• cadena SMILES: [Cl-].CCCCCCCCCCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C
• InChI: 1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/m1./s1
• Clave InChI: GAMKNLFIHBMGQT-ZMBIFBSDSA-N

Descripción

Aplicación

Palmitoyl-L-carnitine chloride has been used as acylcarnitine in treating cardiomyocytes for the induction of reactive oxygen species (ROS).[1]

Acciones bioquímicas o fisiológicas

Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves