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P0099

Sigma-Aldrich

Paliperidone

≥98% (HPLC)

Sinónimos:

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

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About This Item

Fórmula empírica (notación de Hill):
C23H27FN4O3
Número de CAS:
144598-75-4
Peso molecular:
426.48
MDL number:
MFCD00871802
UNSPSC Code:
12352200
PubChem Substance ID:
329820012
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 2 mg/mL, clear (warmed)

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1

InChI

1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

InChI key

PMXMIIMHBWHSKN-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813) , HTR2A(3356)

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Application

Paliperidone has been used as an atypical antipsychotic drug (AAPD) to study its efficacy in preventing psychopathology of mice prenatally immune challenged with lipopolysaccharide (LPS). It has also been used as an atypical antipsychotic drug (AAPD) to explain the modulation of hypothalamic-pituitary-adrenal (HPA) axis in female mice prenatally treated with bacterial endotoxin lipopolysaccharide (LPS).

Biochem/physiol Actions

Paliperidone is an atypical antipsychotic; active metabolite of risperidone.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Umesh Kumar et al.
European journal of pharmacology, 747, 181-189 (2014-09-23)
Studies on animal models provide enough evidences that old age appearance of psychosis on exposures to various insults during critical period of brain development could be prevented by antipsychotic drug treatment. Presently, gestational intervention of the atypical antipsychotic paliperidone (PAL)
Eliyahu Dremencov et al.
Psychopharmacology, 194(1), 63-72 (2007-05-29)
Paliperidone (9-OH-risperidone) is the main metabolite of the atypical antipsychotic risperidone. While both drugs are potent dopamine (D)2 antagonists, they have quantitative differential affinities for serotonin (5-HT) and norepinephrine (NE) receptor binding sites. The present study aimed to determine if
Pierre S Chue et al.
Expert review of neurotherapeutics, 12(12), 1399-1410 (2012-12-15)
Paliperidone, or 9-hydroxyrisperidone (Invega(®), Janssen, Antwerp, Belgium) is the major active metabolite of the atypical antipsychotic risperidone (Risperdal(®), Janssen). It possesses a similar, though not identical, receptor pharmacology to the parent molecule. There are additional differences in terms of its
Yvette Roke et al.
Journal of child and adolescent psychopharmacology, 22(6), 432-439 (2012-12-14)
The aim of this study was to investigate the long-term treatment effects of risperidone on prolactin levels and prolactin-related side effects in pubertal boys with autism spectrum disorders (ASD) and disruptive behavior disorders (DBD). Physical healthy 10-20-year-old males with ASD
Mehrul Hasnain et al.
CNS drugs, 28(10), 887-920 (2014-08-30)
We comprehensively reviewed published literature to determine whether it supported the link between corrected QT (QTc) interval prolongation and torsade de pointes (TdP) for the 11 second-generation antipsychotics and seven second-generation antidepressants commonly implicated in these complications. Using PubMed and
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