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M7441

Sigma-Aldrich

Monoamine Oxidase B human

recombinant, expressed in baculovirus infected BTI insect cells

Sinónimos:

MAO-B

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About This Item

Comisión internacional de enzimas:
1.4.3.4 (BRENDA, IUBMB)
MDL number:
MFCD04040933
UNSPSC Code:
12352204
NACRES:
NA.54

recombinant

expressed in baculovirus infected BTI insect cells

Quality Level

100

form

liquid

enzyme activity

≥1 U/mg

packaging

vial of ~2.5 mg

UniProt accession no.

P27338

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MAOB(4129)

General description

Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs.

Application

Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression.
Monoamine Oxidase B has been used in a study to assess the effect of age in 23 different regions of the human brain. It has also been used in a study to determine the specific locations of monoamine oxidase in the human brain.

Biochem/physiol Actions

MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.

Unit Definition

kynuramine deamination activity: One unit will deaminate 1 nanomole of kynuramine per minute at pH 7.4 at 37 deg C.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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K N Westlund et al.
Neuroscience, 25(2), 439-456 (1988-05-01)
Monoclonal antibodies, specific for either monoamine oxidases A or B, were used to determine the localization of monoamine oxidase in the human brain. Two distinct populations of neurons were detected by immunocytochemical staining. Neurons in regions rich in catecholamines were
The effect of age on the activity and molecular properties of human brain monoamine oxidase
Fowler, C., et al.
Journal of Neural Transmission. General Section, 49, 1-20 (1980)
Aiko Ishiki et al.
Acta neuropathologica communications, 6(1), 53-53 (2018-07-01)
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an imaging-pathology correlation study in
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., et al.
Nature Structural Biology, 9, 22-26 (2001)
Dorota Łażewska et al.
Molecules (Basel, Switzerland), 26(12) (2021-07-03)
Neurodegenerative diseases, e.g., Alzheimer's disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but interconnected targets can
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