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Merck
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M3199

Sigma-Aldrich

MK-212 hydrochloride

≥98% (HPLC)

Sinónimos:

2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride, 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride, NSC 31732

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About This Item

Fórmula empírica (notación de Hill):
C8H11ClN4·HCl
Número de CAS:
61655-58-1
Peso molecular:
235.11
Número CE:
262-883-0
Número MDL:
MFCD00673963
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329817966
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

condiciones de almacenamiento

desiccated

color

white to off-white

solubilidad

DMSO: ≥20 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

Cl.Clc1cncc(n1)N2CCNCC2

InChI

1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H

Clave InChI

PFIZGLUIYAZQFU-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

Selective 5-HT2C serotonin receptor agonist.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
080M4602

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Janet L Neisewander et al.
Behavioural pharmacology, 18(8), 791-800 (2007-11-09)
The extinction/reinstatement model has been used in this study to examine the role of 5-HT2C receptors in cocaine-seeking behavior elicited by cocaine-associated cues and cocaine-priming injections. Rats that had been trained to press a lever for cocaine (0.75 mg/kg/0.1 ml
Nathan S Pentkowski et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(10), 2037-2048 (2010-06-04)
Serotonin 2C receptor (5-HT(2C)R) agonists administered systemically attenuate both cocaine-primed and cue-elicited reinstatement of extinguished cocaine-seeking behavior. To further elucidate the function of these receptors in addiction-like processes, this study examined the effects of microinfusing the 5-HT(2C)R agonist MK212 (0
Antonio Pedro de Mello Cruz et al.
Psychopharmacology, 182(3), 345-354 (2005-09-01)
Although 5-HT2 receptors seem to play an important role in anxiety, results from numerous studies are still highly variable. Moreover, little is known about the behavioral effects of centrally administered 5-HT2 compounds in animal models of anxiety. The current study
K S Gomes et al.
Progress in neuro-psychopharmacology & biological psychiatry, 33(7), 1261-1269 (2009-07-25)
A single exposure to the elevated plus-maze test (EPM) increases open arms avoidance and reduces or abolishes the anxiolytic-like effect of benzodiazepines assessed during a second trial, a phenomenon defined as "one-trial tolerance" (OTT). It has been emphasized that the
Julie D Ross et al.
Drug and alcohol dependence, 81(2), 117-127 (2005-08-02)
3,4-Methylenedioxymethamphetamine [MDMA; ecstasy] evokes a multifaceted subjective experience in human users which includes stimulation, feelings of well-being, mood elevation, empathy towards others as well as distortions in time, sensation and perception. Aspects of this unique psychopharmacology of MDMA are thought
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