We have not done any such testing, but the following references may be helpful: https://jpet.aspetjournals.org/cgi/content/abstract/320/3/1013, https://molpharm.aspetjournals.org/cgi/reprint/66/1/187.
L9908
LY-294,002 hydrochloride
from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor
Sinónimos:
2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
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About This Item
Fórmula empírica (notación de Hill):
C19H17NO3 · HCl
Número de CAS:
Peso molecular:
343.80
Número MDL:
Código UNSPSC:
12352207
ID de la sustancia en PubChem:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad
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Nombre del producto
LY-294,002 hydrochloride, solid, ≥98% (HPLC)
origen biológico
microbial (Staphylococcus roseus)
Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
solid
color
white to off-white
solubilidad
DMSO: >5 mg/mL
H2O: insoluble
temp. de almacenamiento
2-8°C
cadena SMILES
O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
InChI
1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
Clave InChI
CZQHHVNHHHRRDU-UHFFFAOYSA-N
Descripción general
LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K).[1] LY-294,002 inhibits nuclear factor kappa B signaling in macrophages.[2] It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric[3] and nasopharyngeal cancer cells.[4] LY-294,002 modulates action potential repolarization and improves myocyte contractility.[5]
Aplicación
Acciones bioquímicas o fisiológicas
Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
Características y beneficios
This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Can I use Product L9908, LY-294,002 hydrochloride, in conjugation with Wortmannin?
1 answer-
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What is the solution stability in DMSO for Product L9908, LY-294,002 hydrochloride?
1 answer-
After reconstitution in DMSO, aliquot and freeze the stock solution at -20 °C. DMSO stock solutions are stable for at least 1 month at -20 °C.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the recommended concentration for using Product L9908, LY-294,002 hydrochloride?
1 answer-
One can use this product at 50 uM concentration.
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