IgM is a pentameric immunoglobulin, with each monomer having a light and heavy chain. The two types of IgM comprise natural and adaptive.
Aplicación
Anti-Human IgM (μ-chain specific) antibody produced in rabbit has been used in enzyme linked immunosorbent assay.
Acciones bioquímicas o fisiológicas
IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
IgM serves as prime antibody in providing defense. It activates complement C1q. It is regarded as a marker for identifying tumor-associated antigens. Hyper-IgM syndrome is implicated with high IgM levels accompanied by low IgA, IgG and IgE levels.
Nota de preparación
treated to remove lipoproteins
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
The Journal of Allergy and Clinical Immunology, 129(6), 1692-1692 (2012)
The human IgM pentamer is a mushroom-shaped molecule with a flexural bias
Czajkowsky DM and Shao Z
Proceedings of the National Academy of Sciences of the USA, 106(35), 14960-14965 (2009)
Natural and adaptive IgM antibodies in the recognition of tumor-associated antigens of breast cancer
Diaz-Zaragoza M, et al.
Oncology Reports, 34(3), 1106-1114 (2015)
Antibodies reacting with human immunoglobulin in sera from autoimmune thyroid disease patients as a risk factor for false positive results in IgA assessment
Haroun M and El-Masry MH
Central European Journal of Immunology, 33, 208-212 (2008)
Journal of immunology (Baltimore, Md. : 1950), 160(12), 5979-5989 (1998-06-24)
Previous studies have discerned two forms of polymeric mouse IgM: moderately cytolytic (complement-activating) pentamer, which contains J chain, and highly cytolytic hexamer, which lacks J chain. To investigate the relationships among polymeric structure, J chain content, and cytolytic activity, we
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