H6666
Keratinocyte Growth Factor human
HumanKine®, >95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
Sinónimos:
FGF-7, KGF
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Nombre del producto
Keratinocyte Growth Factor human, KGF, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
origen biológico
human
Nivel de calidad
recombinante
expressed in HEK 293 cells
Ensayo
>95% (SDS-PAGE)
Formulario
lyophilized powder
potencia
4-20 ng/mL EC50
calidad
endotoxin tested
mol peso
dimer 17-30 kDa (glycosylated)
envase
pkg of 10 μg
técnicas
cell culture | mammalian: suitable
impurezas
<1 EU/μg
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... FGF7(2252)
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Descripción general
Aplicación
Keratinocyte Growth Factor (KGF) human has been used as a component of the keratinocyte differentiation medium.[4]
Acciones bioquímicas o fisiológicas
Keratinocyte Growth Factor (KGF) exerts paracrine effects on mesenchymal cells. It exhibits cryoprotective effects on epithelial cells of the lungs, gastrointestinal tract, and the lungs.[1] KGF participates in the activation of IIIb isoform of the fibroblast growth factor (FGF)-receptor 2 (FGFR2-IIIb) present on keratinocytes. This activation further favors proliferation, migration, and survival of keratinocytes.[2]
Forma física
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Nota de preparación
HumanKine Keratinocyte Growth Factor (KGF) is expressed as glycosylated 17 and 30 kDa monomers in human HEK 293 cells. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Nota de análisis
The activity was determined by the dose-dependent stimulation of the proliferation of 4MBr-5 cells (monkey epithelial cell line).
Información legal
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
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Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Qandeel Fatima et al.
Open life sciences, 13, 544-552 (2018-12-31)
Autologous skin grafts are used to treat severe burn wounds, however, the availability of adequate donor sites makes this option less practical. Recently, stem cells have been used successfully in tissue engineering and in regenerative medicine. The current study aims
Michael J LaFemina et al.
American journal of physiology. Lung cellular and molecular physiology, 299(6), L724-L734 (2010-09-14)
Keratinocyte growth factor (KGF) has efficacy in several experimental models of lung injury; however, the mechanisms underlying KGF's protective effect remain incompletely understood. This study was undertaken to determine whether KGF augments barrier function in primary rat alveolar epithelial cells
Verônica Chomiski et al.
Acta cirurgica brasileira, 31(8), 505-512 (2016-09-01)
To evaluate the effect of keratinocyte growth factor (KGF) treatment on the expression of wound-healing-related genes in cultured keratinocytes from burn patients. Keratinocytes were cultured and divided into 4 groups (n=4 in each group): TKB (KGF-treated keratinocytes from burn patients)
Umbilical cord tissue derived mesenchymal stem cells can differentiate into skin cells
Fatima Q, et al.
The Open Immunology Journal, 13(1), 544-552 (2018)
Susanne Braun et al.
Journal of cell science, 119(Pt 23), 4841-4849 (2006-11-09)
Owing to its potent cytoprotective properties for epithelial cells, keratinocyte growth factor (KGF) is successfully used for the treatment of chemotherapy- and radiotherapy-induced oral mucositis in cancer patients. It is therefore of major interest to determine possible clinical applications of
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