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H0536

Sigma-Aldrich

Hepatocyte Growth Factor Receptor (c-Met)/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sinónimos:

HGF Receptor (c-Met)

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About This Item

MDL number:
MFCD01867051
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

100

recombinant

expressed in NSO cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

0.1-5 ng/mL

mol wt

calculated mol wt 129 kDa

packaging

pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

P08581

storage temp.

−20°C

Gene Information

human ... MET(4233)

Biochem/physiol Actions

Heterodimeric transmembrane glycoprotein with binding capacity for c-Met. Activation of this receptor has been correlated with induction of the Ras pathway.

Other Notes

Extracellular domain of c-Met fused to the C-terminal 6X histidine-tagged Fc region of human IgG1.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing 5 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to bind human HGF.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Yaroslava M Chalenko et al.
International journal of molecular sciences, 24(8) (2023-04-28)
Listeria monocytogenes virulence factor InlB specifically interacts with the receptors c-Met and gC1q-R. Both receptors are present in non-professional and professional phagocytes, including macrophages. Phylogenetically defined InlB isoforms differently support invasion into non-professional phagocytes. This work deals with the effects
M Park et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(18), 6379-6383 (1987-09-01)
We isolated overlapping cDNA clones corresponding to the major MET protooncogene transcript. The cDNA nucleotide sequence contained an open reading frame of 1408 amino acids with features characteristic of the tyrosine kinase family of growth factor receptors. These features include
Egor V Kalinin et al.
Drug development research, 82(1), 123-132 (2020-08-25)
Hepatocyte growth factor (HGF) is central to liver regeneration. The Internalin B (InlB) protein is a virulence factor produced by the pathogenic bacterium Listeria monocytogenes. InlB is known to mimic HGF activity by interacting with the HGF receptor (HGFR) and
Xin Li et al.
Frontiers in cell and developmental biology, 9, 661122-661122 (2021-05-04)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with minimally effective treatments, highlighting the importance of developing novel biomarkers and therapeutic targets. Here, we disclosed the mechanisms that leukocyte cell-derived chemotaxin-2 (LECT2) modulates PDAC development using in

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