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Merck

G0424

Sigma-Aldrich

Corilagin

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About This Item

Fórmula empírica (notación de Hill):
C27H22O18
Número de CAS:
Peso molecular:
634.45
Número MDL:
Código UNSPSC:
12352205
ID de la sustancia en PubChem:
NACRES:
NA.25

Ensayo

≥98% (HPLC)

Nivel de calidad

Formulario

powder

solubilidad

H2O: 1 mg/mL, clear, colorless

aplicaciones

metabolomics
vitamins, nutraceuticals, and natural products

temp. de almacenamiento

2-8°C

cadena SMILES

O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c4c(O)c(O)c(O)cc4C(=O)O[C@@H]1[C@@H](O)[C@@H](O2)OC(=O)c5cc(O)c(O)c(O)c5

InChI

1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2/t13-,19-,22-,23+,27+/m1/s1

Clave InChI

TUSDEZXZIZRFGC-XIGLUPEJSA-N

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Descripción general

Corilagin is a polyphenolic tannic acid and a major bioactive compound present in various plant species. It is an active component of Phyllanthus urinaria and Terminalia catappa L extract used to treat various ailments.

Aplicación

Corilagin has been used to study its inhibitory effect on the growth of breast cancer by inducing apoptosis and autophagy regulated by the release of reactive oxygen species.

Acciones bioquímicas o fisiológicas

Corilagin is a polyphenol, specifically a hydrolyzable tannin, found in Traditional Chinese Medicine herbal preparations. It is reported to have anti-inflammatory and anti-tumor activities.
Corilagin shows a variety of biological activities such as anti-inflammatory, anti-viral, anti-oxidant, hepatoprotective, antibacterial, anti-coagulant, hypolipemic and hypotensive. It has been noted to possess anti-tumor, antiproliferative, apoptotic, and autophagic abilities as well. Corilagin has been found to reduce the minimum inhibitory concentration (MIC) of β-lactams against Methicillin-resistant Staphylococcus aureus (MRSA).

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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M Shimizu et al.
Antimicrobial agents and chemotherapy, 45(11), 3198-3201 (2001-10-16)
We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of beta-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various
Christian Agyare et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(7), 617-624 (2010-11-03)
Leaves from Phyllanthus muellerianus (Kuntze) Exell. are traditionally used for wound healing in Western Africa. Aqueous extracts of dried leaves recently have been shown to stimulate proliferation of human keratinocytes and dermal fibroblasts. Within bioassay-guided fractionation the ellagitannins geraniin (1)
K Nagendra Prasad et al.
Journal of pharmaceutical and biomedical analysis, 51(2), 471-477 (2009-04-07)
The health benefits of fruits acting against chronic diseases are ascribed to their antioxidant activities which are mainly responsible due to the presence of phenolic compounds. The use of ultra-high-pressure-assisted extraction (UHPE) has shown great advantages for the extraction of
Nuchanart Rangkadilok et al.
Fitoterapia, 83(3), 545-553 (2012-01-17)
Longan, Dimocarpus longan Lour., contains polyphenolic compounds which exhibit several pharmacological properties. This study aims to evaluate antifungal activities of longan fruit extract in comparison to its active compounds. The results showed that longan seed exhibited antifungal activity against the
Luoqi Jia et al.
BMC complementary and alternative medicine, 13, 33-33 (2013-02-16)
Phyllanthus niruri L. is a well-known hepatoprotective and antiviral medicinal herb. Recently, we identified Corilagin as a major active component with anti-tumor activity in this herbal medicine. Corilagin is a member of the tannin family that has been discovered in

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