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Key Documents

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F8791

Sigma-Aldrich

5-Fluoro-5′-deoxyuridine

Sinónimos:

Doxifluridine, 5′dFUrd

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About This Item

Fórmula empírica (notación de Hill):
C9H11FN2O5
Número de CAS:
3094-09-5
Peso molecular:
246.19
EC Number:
221-440-1
MDL number:
MFCD00866530
UNSPSC Code:
12352200
PubChem Substance ID:
24278444
NACRES:
NA.77

Quality Level

200

SMILES string

C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O

InChI

1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1

InChI key

ZWAOHEXOSAUJHY-ZIYNGMLESA-N

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Biochem/physiol Actions

Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Hitoshi Miyakoshi et al.
Journal of medicinal chemistry, 55(7), 2960-2969 (2012-03-13)
Recently, deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as part of a new strategy of 5-fluorouracil-based combination chemotherapy. We have initiated a program to develop potent drug-like dUTPase inhibitors based on structure-activity relationship (SAR) studies
G J Peters et al.
International journal of cancer, 54(3), 450-455 (1993-05-28)
Malignant activation of oncogenes ras or trk is implicated in a number of solid tumors and leukemias. We determined the chemosensitivity profile of wild-type mouse NIH-3T3 fibroblasts, and that of NIH-3T3 lines transformed by the H-ras (S2-721) and trk (106-632)
Linda Connelly et al.
Breast cancer research : BCR, 13(4), R83-R83 (2011-09-03)
Metastasis from primary tumor to the lungs is a major cause of the mortality associated with breast cancer. Both immune and inflammatory responses impact whether circulating mammary tumor cells successfully colonize the lungs leading to established metastases. Nuclear factor -kappaB
Yasuko Naganuma et al.
Cancer science, 102(8), 1545-1552 (2011-06-03)
Uterine carcinosarcoma is a highly aggressive gynecological neoplasm that responds poorly to conventional chemotherapy and radiotherapy. Metronomic chemotherapy is accepted as a new approach for cancer treatment, and its underlying mechanism seems to involve the suppression of angiogenesis. However, the
Dengke Pan et al.
Chemical communications (Cambridge, England), 47(3), 908-910 (2010-11-17)
Nearly monodispersed magnetic Fe(3)O(4)@DFUR-LDH submicro particles containing the anticancer agent DFUR were prepared via a coprecipitation-calcination-reconstruction strategy of LDH materials over the surface of Fe(3)O(4) particles, and present well-defined core-shell structure, strong magnetization and obvious magnetically controlled drug delivery and
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