F3422
Flt-3/Flk-2 ligand human
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC)
Sinónimos:
FL
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origen biológico
human
Nivel de calidad
recombinante
expressed in E. coli
Ensayo
≥98% (SDS-PAGE and HPLC)
Formulario
lyophilized powder
potencia
≤1.0 ng/mL
mol peso
17.6 kDa
envase
pkg of 5 μg
condiciones de almacenamiento
avoid repeated freeze/thaw cycles
técnicas
cell culture | mammalian: suitable
impurezas
endotoxin, tested
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... FLT3(2322)
Descripción general
Mouse and human Flt-3 ligand share ~72% homology and both demonstrate cross-species activity.
Acciones bioquímicas o fisiológicas
Flt-3/Flk-2 Ligand (FL, or Flt-3L) is a transmembrane glycoprotein that binds and activates the Flt-3 receptor. Expression of Flt-3 is primarily restricted among hematopoietic cells to the most primitive progenitor cells.
Forma física
Lyophilized, 0.2 μm sterile filtered, with with 0.5x PBS.
Nota de análisis
The biological activity is measured by its ability to stimulate the proliferation of human AML5 cells.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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H G Drexler et al.
Leukemia & lymphoma, 33(1-2), 83-91 (1999-04-08)
FLT3 ligand (FL) acting through its tyrosine kinase receptor FLT3 has pleiotropic and potent effects on hematopoietic cells. The well-described involvement of this ligand-receptor pair in physiological hematopoiesis raised the question whether FL and FLT3 also play a role in
S D Lyman et al.
Oncogene, 8(4), 815-822 (1993-04-01)
We have developed rabbit polyclonal antibodies to the C-terminus of the flt3-encoded protein, which is a member of the receptor tyrosine kinase family. Immunoprecipitation using this antiserum brings down two protein bands, a major band of 143 kDa and a
Lyman, S., et al. et al.
The Cytokine Handbook, 727-727 (1998)
R Namikawa et al.
Stem cells (Dayton, Ohio), 14(4), 388-395 (1996-07-01)
The biological activities of the ligand for the Flk2/Flt3 receptor tyrosine kinase (FL) on human hematopoietic cells are reviewed. In in vitro studies, FL shows relatively few effects by itself on the proliferation and differentiation of hematopoietic cells, but exhibits
O Rosnet et al.
Oncogene, 6(9), 1641-1650 (1991-09-01)
Receptor-type tyrosine kinases presenting an extracellular region with five immunoglobulin-like domains, and strongly related by sequence similarities in the intracellular region, constitute a family of receptors involved in development and function of various cell lineages. We have isolated and characterized
Artículos
Read article on hematopoietic cytokines and hematopoiesis
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