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F0429

Sigma-Aldrich

Flunixin meglumine

≥98% (HPLC)

Sinónimos:

2-[[2-Methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid meglumine salt, Banamine

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About This Item

Fórmula empírica (notación de Hill):
C14H11F3N2O2·C7H17NO5
Número de CAS:
42461-84-7
Peso molecular:
491.46
EC Number:
255-836-0
MDL number:
MFCD01725419
UNSPSC Code:
12352200
PubChem Substance ID:
24724478
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

mp

136.6-137.4 °C

solubility

H2O: freely soluble

storage temp.

room temp

SMILES string

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F

InChI

1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

InChI key

MGCCHNLNRBULBU-WZTVWXICSA-N

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Application

Flunixin meglumine has been used as a nonsteroidal anti-inflammatory drug standard in electrospray ionization mass spectrometry (LC-ESI/MS).
Flunixin meglumine (IC50 = 1 nM) can be used as a drug for animals for the management of intestinal ischaemia, colic, and endotoxemia in horses.

Biochem/physiol Actions

Flunixin meglumine is a nonsteroidal anti-inflammatory drug, which blocks prostaglandin synthesis.
COX1, COX2 and PLA2 inhibitor non-narcotic analgesic, anti-pyretic, anti-inflammatory.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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A Review on Flunixin Meglumine
Faiza H, et al.
International journal of medicine and medical research, 1(2), 136-138 (2016)
A J Morton et al.
Equine veterinary journal. Supplement, (39)(39), 112-116 (2011-08-04)
The effects of prostaglandins and nonsteroidal anti-inflammatory drugs (NSAIDs) on repair of equine intestinal mucosa are important since most horses with gastrointestinal diseases are routinely treated with NSAIDs, such as flunixin meglumine (FM), and these drugs can be toxic to
Analysis of nine NSAIDs in ungulate tissues available to critically endangered vultures in India
Taggart MA, et al.
Environmental Science & Technology, 43(12), 4561-4566 (2009)
J Cuervo-Arango et al.
Theriogenology, 77(3), 514-524 (2011-10-01)
The development of hemorrhagic anovulatory follicles (HAF) involves luteinization and hemorrhage of the follicle. This is observed on ultrasound as an increase in the echogenicity of the granulosa layer and formation of echoic particles in the antrum. The inhibition of
G Pugliesi et al.
Theriogenology, 78(2), 443-454 (2012-05-15)
The beginning of postluteolysis (progesterone, <1 ng mL(-1)) in heifers was targeted by using 8 h after ultrasonic detection of a 25% decrease in CL area (cm2) and was designated Hour 0. Flunixin meglumine (FM; n=10) to inhibit PGF2α secretion
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