D4813
Dendrotoxin-K
≥98% (HPLC), lyophilized powder
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About This Item
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Application
Dendrotoxin-K is suitable for use as a potassium voltage-gated channel subfamily A member 1 (Kv1.1) channel blocker in axon and human embryonic kidney (HEK293) cells. It has also been used as a selective blocker of Kv channels in mice.
Biochem/physiol Actions
Dendrotoxin-K (DTXk) is isolated from mamba snake Dendroaspis polylepis and interacts with the β-turn region in the N-terminal sequence of the potassium channel. It inhibits tumor progression in gefitinib-resistant non-small cell lung cancer cells. DTXk induces neuronal damage in the hippocampus via N-methyl-d-aspartate (NMDA) and non-NMDA receptors.
Dendrotoxin-K inhibits potassium channels that contain Kv1.1 protein only.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes
Isolated initially from Dendroaspis polylepis polylepis venom
Preparation Note
Purified by a modification of the method of Schweitz.
Reconstitution
Reconstitute in 1 mL deionized water or buffer (pH 7.5) to yield 10 μM stock
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
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Cav1. 3 calcium channels are required for normal development of the auditory brainstem
Hirtz JJ, et al.
The Journal of Neuroscience, 31(22), 8280-8294 (2011)
Effects of voltage-gated K+ channel blockers in gefitinib-resistant H460 non-small cell lung cancer cells
Jeon WIL, et al.
Anticancer Research, 32(12), 5279-5284 (2012)
Identification of residues in dendrotoxin K responsible for its discrimination between neuronal K+ channels containing Kv1. 1 and 1.2 alpha subunits
Wang FC, et al.
European Journal of Biochemistry, 263(1), 222-229 (1999)
F C Wang et al.
European journal of biochemistry, 263(1), 222-229 (1999-08-03)
Dendrotoxin (DTX) homologues are powerful blockers of K+ channels that contain certain subfamily Kv1 (1.1-1.6) alpha- and beta-subunits, in (alpha)4(beta)4 stoichiometry. DTXk inhibits potently Kv1.1-containing channels only, whereas alphaDTX is less discriminating, but exhibits highest affinity for Kv1.2. Herein, the
Analog modulation of spike-evoked transmission in CA 3 circuits is determined by axonal K v1. 1 channels in a time-dependent manner
Bialowas A, et al.
The European Journal of Neuroscience, 41(3), 293-304 (2015)
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